Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AI019047-15
Application #
2060856
Study Section
Immunobiology Study Section (IMB)
Project Start
1981-09-01
Project End
1998-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
15
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Harvard University
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
071723621
City
Cambridge
State
MA
Country
United States
Zip Code
02138
Menges, Paula R; Jenks, Scott A; Bikoff, Elizabeth K et al. (2008) An MHC class II restriction bias in CD4 T cell responses toward I-A is altered to I-E in DM-deficient mice. J Immunol 180:1619-33
Koonce, Chad H; Bikoff, Elizabeth K (2004) Dissecting MHC class II export, B cell maturation, and DM stability defects in invariant chain mutant mice. J Immunol 173:3271-80
Ye, Qiang; Finn, Patricia W; Sweeney, Ruth et al. (2003) MHC class II-associated invariant chain isoforms regulate pulmonary immune responses. J Immunol 170:1473-80
Koonce, Chad H; Wutz, Gordana; Robertson, Elizabeth J et al. (2003) DM loss in k haplotype mice reveals isotype-specific chaperone requirements. J Immunol 170:3751-61
Fiebiger, Edda; Maehr, Rene; Villadangos, Jose et al. (2002) Invariant chain controls the activity of extracellular cathepsin L. J Exp Med 196:1263-9
Bikoff, E K; Wutz, G; Kenty, G A et al. (2001) Relaxed DM requirements during class II peptide loading and CD4+ T cell maturation in BALB/c mice. J Immunol 166:5087-98
Kenty, G; Bikoff, E K (1999) BALB/c invariant chain mutant mice display relatively efficient maturation of CD4+ T cells in the periphery and secondary proliferative responses elicited upon peptide challenge. J Immunol 163:232-41
Wright, R J; Bikoff, E K; Stockinger, B (1998) The Ii41 isoform of invariant chain mediates both positive and negative selection events in T-cell receptor transgenic mice. Immunology 95:309-13
Bikoff, E K; Kenty, G; Van Kaer, L (1998) Distinct peptide loading pathways for MHC class II molecules associated with alternative Ii chain isoforms. J Immunol 160:3101-10
Kenty, G; Martin, W D; Van Kaer, L et al. (1998) MHC class II expression in double mutant mice lacking invariant chain and DM functions. J Immunol 160:606-14

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