Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AI021301-12
Application #
2061458
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1984-07-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Michigan Ann Arbor
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

Filippov, Sergey; Caras, Ingrid; Murray, Richard et al. (2003) Matrilysin-dependent elastolysis by human macrophages. J Exp Med 198:925-35
Punturieri, A; Filippov, S; Allen, E et al. (2000) Regulation of elastinolytic cysteine proteinase activity in normal and cathepsin K-deficient human macrophages. J Exp Med 192:789-99
Ho, N; Punturieri, A; Wilkin, D et al. (1999) Mutations of CTSK result in pycnodysostosis via a reduction in cathepsin K protein. J Bone Miner Res 14:1649-53
Reddy, V Y; Zhang, Q Y; Weiss, S J (1995) Pericellular mobilization of the tissue-destructive cysteine proteinases, cathepsins B, L, and S, by human monocyte-derived macrophages. Proc Natl Acad Sci U S A 92:3849-53
Rice, W G; Weiss, S J (1990) Regulation of proteolysis at the neutrophil-substrate interface by secretory leukoprotease inhibitor. Science 249:178-81
Weiss, S J (1989) Tissue destruction by neutrophils. N Engl J Med 320:365-76
Peppin, G J; Weiss, S J (1986) Activation of the endogenous metalloproteinase, gelatinase, by triggered human neutrophils. Proc Natl Acad Sci U S A 83:4322-6
Weiss, S J; Peppin, G; Ortiz, X et al. (1985) Oxidative autoactivation of latent collagenase by human neutrophils. Science 227:747-9