Abstract

The objective of this proposal is to characterize the transmission of the putative AIDS agent (HTLV III) in the sexual partners and children of Haitian AIDS patients and to determine the natural history of the infection in the affected family members. We will determine the prevalence of HTLV III seropositivity, and seroconversion rates in the sexual partners and children. We will compare and contrast the AIDs families with similar studies of age-sex matched friends of the AIDS sexual partner. The children of these friends will serve as controls for the children of the AIDS families. HTLV III seropositive subjects (children and adults) will be followed for periods of 1-4 years to determine the natural history of this infection. Evidence for vertical and horizontal infection within families will be sought. HTLV III viral isolation studies of pregnant women and young children will assist in this determination. We will examine sexual and non-sexual activities of the study subjects to determine if particular activities are associated with acquisition of HTLV III infection or influence the natural history of the infection.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AI022624-09
Application #
3481198
Study Section
Special Emphasis Panel (ARR (V1))
Project Start
1985-07-01
Project End
1995-04-30
Budget Start
1993-05-01
Budget End
1994-04-30
Support Year
9
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
Weill Medical College of Cornell University
Department
Type
Schools of Medicine
DUNS #
201373169
City
New York
State
NY
Country
United States
Zip Code
10065

  Publications

Bonecini-Almeida, M Gloria; Ho, John L; Boechat, Neio et al. (2004) Down-modulation of lung immune responses by interleukin-10 and transforming growth factor beta (TGF-beta) and analysis of TGF-beta receptors I and II in active tuberculosis. Infect Immun 72:2628-34
Peck, Robert; Fitzgerald, Daniel W; Liautaud, Bernard et al. (2003) The feasibility, demand, and effect of integrating primary care services with HIV voluntary counseling and testing: evaluation of a 15-year experience in Haiti, 1985-2000. J Acquir Immune Defic Syndr 33:470-5
Burgess, A L; Fitzgerald, D W; Severe, P et al. (2001) Integration of tuberculosis screening at an HIV voluntary counselling and testing centre in Haiti. AIDS 15:1875-9
Desvarieux, M; Hyppolite, P R; Johnson Jr, W D et al. (2001) A novel approach to directly observed therapy for tuberculosis in an HIV-endemic area. Am J Public Health 91:138-41
Verdier, R I; Fitzgerald, D W; Johnson Jr, W D et al. (2000) Trimethoprim-sulfamethoxazole compared with ciprofloxacin for treatment and prophylaxis of Isospora belli and Cyclospora cayetanensis infection in HIV-infected patients. A randomized, controlled trial. Ann Intern Med 132:885-8
Deschamps, M M; Fitzgerald, D W; Pape, J W et al. (2000) HIV infection in Haiti: natural history and disease progression. AIDS 14:2515-21
Fitzgerald, D W; Desvarieux, M; Severe, P et al. (2000) Effect of post-treatment isoniazid on prevention of recurrent tuberculosis in HIV-1-infected individuals: a randomised trial. Lancet 356:1470-4
Fitzgerald, D W; Morse, M M; Pape, J W et al. (2000) Active tuberculosis in individuals infected with human immunodeficiency virus after isoniazid prophylaxis. Clin Infect Dis 31:1495-7
Jean, S S; Pape, J W; Verdier, R I et al. (1999) The natural history of human immunodeficiency virus 1 infection in Haitian infants. Pediatr Infect Dis J 18:58-63
Bonecini-Almeida, M G; Chitale, S; Boutsikakis, I et al. (1998) Induction of in vitro human macrophage anti-Mycobacterium tuberculosis activity: requirement for IFN-gamma and primed lymphocytes. J Immunol 160:4490-9

Showing the most recent 10 out of 26 publications