Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AI023682-20
Application #
6879042
Study Section
Special Emphasis Panel (NSS)
Program Officer
Rogers, Martin J
Project Start
1983-06-01
Project End
2008-03-31
Budget Start
2005-04-01
Budget End
2006-03-31
Support Year
20
Fiscal Year
2005
Total Cost
$375,409
Indirect Cost
Name
Oregon Health and Science University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239
Boitz, Jan M; Jardim, Armando; Ullman, Buddy (2016) GMP reductase and genetic uncoupling of adenylate and guanylate metabolism in Leishmania donovani parasites. Mol Biochem Parasitol 208:74-83
Ortiz, Diana; Forquer, Isaac; Boitz, Jan et al. (2016) Targeting the Cytochrome bc1 Complex of Leishmania Parasites for Discovery of Novel Drugs. Antimicrob Agents Chemother 60:4972-82
Smith, Sabrina; Boitz, Jan; Chidambaram, Ehzilan Subramanian et al. (2016) The cystathionine-?-synthase domains on the guanosine 5''-monophosphate reductase and inosine 5'-monophosphate dehydrogenase enzymes from Leishmania regulate enzymatic activity in response to guanylate and adenylate nucleotide levels. Mol Microbiol 100:824-40
Soysa, Radika; Tran, Khoa D; Ullman, Buddy et al. (2015) Integrating ribosomal promoter vectors that offer a choice of constitutive expression profiles in Leishmania donovani. Mol Biochem Parasitol 204:89-92
Rodriguez-Contreras, Dayana; Aslan, Hamide; Feng, Xiuhong et al. (2015) Regulation and biological function of a flagellar glucose transporter in Leishmania mexicana: a potential glucose sensor. FASEB J 29:11-24
Martin, Jessica L; Yates, Phillip A; Soysa, Radika et al. (2014) Metabolic reprogramming during purine stress in the protozoan pathogen Leishmania donovani. PLoS Pathog 10:e1003938
Soysa, Radika; Carter, Nicola S; Yates, Phillip A (2014) A dual luciferase system for analysis of post-transcriptional regulation of gene expression in Leishmania. Mol Biochem Parasitol 195:1-5
Boitz, Jan M; Strasser, Rona; Yates, Phillip A et al. (2013) Adenylosuccinate synthetase and adenylosuccinate lyase deficiencies trigger growth and infectivity deficits in Leishmania donovani. J Biol Chem 288:8977-90
Tran, Khoa D; Rodriguez-Contreras, Dayana; Vieira, Danielle P et al. (2013) KHARON1 mediates flagellar targeting of a glucose transporter in Leishmania mexicana and is critical for viability of infectious intracellular amastigotes. J Biol Chem 288:22721-33
Boitz, Jan M; Ullman, Buddy (2013) Adenine and adenosine salvage in Leishmania donovani. Mol Biochem Parasitol 190:51-5

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