Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
2R37AI024134-09A1
Application #
2062452
Study Section
Experimental Virology Study Section (EVR)
Project Start
1987-02-01
Project End
2001-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Washington University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Cristea, Ileana M; Carroll, John-William N; Rout, Michael P et al. (2006) Tracking and elucidating alphavirus-host protein interactions. J Biol Chem 281:30269-78
Gorchakov, Rodion; Frolova, Elena; Williams, Bryan R G et al. (2004) PKR-dependent and -independent mechanisms are involved in translational shutoff during Sindbis virus infection. J Virol 78:8455-67
Gorchakov, Rodion; Hardy, Richard; Rice, Charles M et al. (2004) Selection of functional 5' cis-acting elements promoting efficient sindbis virus genome replication. J Virol 78:61-75
De Francesco, Raffaele; Rice, Charles M (2003) New therapies on the horizon for hepatitis C: are we close? Clin Liver Dis 7:211-42, xi
Hardy, Richard W; Marcotrigiano, Joseph; Blight, Keril J et al. (2003) Hepatitis C virus RNA synthesis in a cell-free system isolated from replicon-containing hepatoma cells. J Virol 77:2029-37
Frolova, Elena I; Fayzulin, Rafik Z; Cook, Susan H et al. (2002) Roles of nonstructural protein nsP2 and Alpha/Beta interferons in determining the outcome of Sindbis virus infection. J Virol 76:11254-64
Kummerer, Beate M; Rice, Charles M (2002) Mutations in the yellow fever virus nonstructural protein NS2A selectively block production of infectious particles. J Virol 76:4773-84
Frolov, I; Hardy, R; Rice, C M (2001) Cis-acting RNA elements at the 5' end of Sindbis virus genome RNA regulate minus- and plus-strand RNA synthesis. RNA 7:1638-51
Qu, L; McMullan, L K; Rice, C M (2001) Isolation and characterization of noncytopathic pestivirus mutants reveals a role for nonstructural protein NS4B in viral cytopathogenicity. J Virol 75:10651-62
Frolov, I; Agapov, E; Hoffman Jr, T A et al. (1999) Selection of RNA replicons capable of persistent noncytopathic replication in mammalian cells. J Virol 73:3854-65

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