Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AI024742-08
Application #
2062713
Study Section
Special Emphasis Panel (NSS)
Project Start
1987-05-01
Project End
1997-04-30
Budget Start
1994-05-01
Budget End
1995-04-30
Support Year
8
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Washington University
Department
Pathology
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Calderon, Boris; Carrero, Javier A; Unanue, Emil R (2014) The central role of antigen presentation in islets of Langerhans in autoimmune diabetes. Curr Opin Immunol 26:32-40
Nayak, Deepak K; Calderon, Boris; Vomund, Anthony N et al. (2014) ZnT8-reactive T cells are weakly pathogenic in NOD mice but can participate in diabetes under inflammatory conditions. Diabetes 63:3438-48
Mohan, James F; Calderon, Boris; Anderson, Mark S et al. (2013) Pathogenic CD4? T cells recognizing an unstable peptide of insulin are directly recruited into islets bypassing local lymph nodes. J Exp Med 210:2403-14
Carrero, Javier A; Calderon, Boris; Towfic, Fadi et al. (2013) Defining the transcriptional and cellular landscape of type 1 diabetes in the NOD mouse. PLoS One 8:e59701
Yang, Chiao-Wen; Unanue, Emil R (2013) Neutrophils control the magnitude and spread of the immune response in a thromboxane A2-mediated process. J Exp Med 210:375-87
Ireland, Jamie M; Unanue, Emil R (2012) Processing of proteins in autophagy vesicles of antigen-presenting cells generates citrullinated peptides recognized by the immune system. Autophagy 8:429-30
Calderon, Boris; Unanue, Emil R (2012) Antigen presentation events in autoimmune diabetes. Curr Opin Immunol 24:119-28
Ireland, Jamie M; Unanue, Emil R (2011) Autophagy in antigen-presenting cells results in presentation of citrullinated peptides to CD4 T cells. J Exp Med 208:2625-32
Edelson, Brian T; Bradstreet, Tara R; KC, Wumesh et al. (2011) Batf3-dependent CD11b(low/-) peripheral dendritic cells are GM-CSF-independent and are not required for Th cell priming after subcutaneous immunization. PLoS One 6:e25660
Calderon, Boris; Carrero, Javier A; Miller, Mark J et al. (2011) Entry of diabetogenic T cells into islets induces changes that lead to amplification of the cellular response. Proc Natl Acad Sci U S A 108:1567-72

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