Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AI025606-10
Application #
2063028
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Project Start
1988-03-01
Project End
1998-02-28
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Washington
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Rosen, Henry; Klebanoff, Seymour J; Wang, Yi et al. (2009) Methionine oxidation contributes to bacterial killing by the myeloperoxidase system of neutrophils. Proc Natl Acad Sci U S A 106:18686-91
Rosen, Henry; Crowley, Jan R; Heinecke, Jay W (2002) Human neutrophils use the myeloperoxidase-hydrogen peroxide-chloride system to chlorinate but not nitrate bacterial proteins during phagocytosis. J Biol Chem 277:30463-8
Staudinger, Benjamin J; Oberdoerster, Michele A; Lewis, Patrick J et al. (2002) mRNA expression profiles for Escherichia coli ingested by normal and phagocyte oxidase-deficient human neutrophils. J Clin Invest 110:1151-63
Rosen, H; Michel, B R; vanDevanter, D R et al. (1998) Differential effects of myeloperoxidase-derived oxidants on Escherichia coli DNA replication. Infect Immun 66:2655-9
Kuhl, S J; Rosen, H (1998) Nitric oxide and septic shock. From bench to bedside. West J Med 168:176-81
Rosen, H; Michel, B R (1997) Redundant contribution of myeloperoxidase-dependent systems to neutrophil-mediated killing of Escherichia coli. Infect Immun 65:4173-8
Rosen, H (1997) Superantigens. Int J Dermatol 36:14-6
Durden, D L; Kim, H M; Calore, B et al. (1995) The Fc gamma RI receptor signals through the activation of hck and MAP kinase. J Immunol 154:4039-47
Rakita, R M; Michel, B R; Rosen, H (1994) Inactivation of Escherichia coli penicillin-binding proteins by human neutrophils. Infect Immun 62:162-5
Durden, D L; Rosen, H; Cooper, J A (1994) Serine/threonine phosphorylation of the gamma-subunit after activation of the high-affinity Fc receptor for immunoglobulin G. Biochem J 299 ( Pt 2):569-77

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