Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AI026791-19
Application #
7084597
Study Section
Special Emphasis Panel (NSS)
Program Officer
Mallia, Conrad M
Project Start
1988-07-01
Project End
2008-06-30
Budget Start
2006-07-01
Budget End
2007-06-30
Support Year
19
Fiscal Year
2006
Total Cost
$399,144
Indirect Cost
Name
Yale University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Jackman, Rachael P; Balamuth, Fran; Bottomly, Kim (2007) CTLA-4 differentially regulates the immunological synapse in CD4 T cell subsets. J Immunol 178:5543-51
Meyer zum Bueschenfelde, Christian O; Unternaehrer, Julia; Mellman, Ira et al. (2004) Regulated recruitment of MHC class II and costimulatory molecules to lipid rafts in dendritic cells. J Immunol 173:6119-24
Balamuth, Fran; Brogdon, Jennifer L; Bottomly, Kim (2004) CD4 raft association and signaling regulate molecular clustering at the immunological synapse site. J Immunol 172:5887-92
Jorritsma, Patricia J; Brogdon, Jennifer L; Bottomly, Kim (2003) Role of TCR-induced extracellular signal-regulated kinase activation in the regulation of early IL-4 expression in naive CD4+ T cells. J Immunol 170:2427-34
Eisenbarth, Stephanie C; Piggott, Damani A; Huleatt, James W et al. (2002) Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen. J Exp Med 196:1645-51
Brogdon, Jennifer L; Leitenberg, David; Bottomly, Kim (2002) The potency of TCR signaling differentially regulates NFATc/p activity and early IL-4 transcription in naive CD4+ T cells. J Immunol 168:3825-32
Constant, Stephanie L; Brogdon, Jennifer L; Piggott, Damani A et al. (2002) Resident lung antigen-presenting cells have the capacity to promote Th2 T cell differentiation in situ. J Clin Invest 110:1441-8
He, Xin; Janeway Jr, Charles A; Levine, Matthew et al. (2002) Dual receptor T cells extend the immune repertoire for foreign antigens. Nat Immunol 3:127-34
Constant, S L; Lee, K S; Bottomly, K (2000) Site of antigen delivery can influence T cell priming: pulmonary environment promotes preferential Th2-type differentiation. Eur J Immunol 30:840-7
Welte, T; Leitenberg, D; Dittel, B N et al. (1999) The PTK-STAT signaling pathway has essential roles in T-cell activation in response to antigen stimulation. Cold Spring Harb Symp Quant Biol 64:291-302

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