Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AI047868-07
Application #
7071218
Study Section
Special Emphasis Panel (NSS)
Program Officer
Minnicozzi, Michael
Project Start
2000-09-01
Project End
2010-02-28
Budget Start
2006-03-01
Budget End
2007-02-28
Support Year
7
Fiscal Year
2006
Total Cost
$339,457
Indirect Cost
Name
University of California Los Angeles
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Schenk, Mirjam; Mahapatra, Sebabrata; Le, Phuonganh et al. (2016) Human NOD2 Recognizes Structurally Unique Muramyl Dipeptides from Mycobacterium leprae. Infect Immun 84:2429-38
Teles, Rosane M B; Kelly-Scumpia, Kindra M; Sarno, Euzenir N et al. (2015) IL-27 Suppresses Antimicrobial Activity in Human Leprosy. J Invest Dermatol 135:2410-2417
Ma, Feng; Liu, Su-Yang; Razani, Bahram et al. (2014) Retinoid X receptor ? attenuates host antiviral response by suppressing type I interferon. Nat Commun 5:5494
Schenk, Mirjam; Fabri, Mario; Krutzik, Stephan R et al. (2014) Interleukin-1? triggers the differentiation of macrophages with enhanced capacity to present mycobacterial antigen to T cells. Immunology 141:174-80
Teles, Rosane M B; Graeber, Thomas G; Krutzik, Stephan R et al. (2013) Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses. Science 339:1448-53
Klug-Micu, Georgiana M; Stenger, Steffen; Sommer, Andrea et al. (2013) CD40 ligand and interferon-? induce an antimicrobial response against Mycobacterium tuberculosis in human monocytes. Immunology 139:121-8
Schenk, Mirjam; Krutzik, Stephan R; Sieling, Peter A et al. (2012) NOD2 triggers an interleukin-32-dependent human dendritic cell program in leprosy. Nat Med 18:555-63
Liu, Philip T; Wheelwright, Matthew; Teles, Rosane et al. (2012) MicroRNA-21 targets the vitamin D-dependent antimicrobial pathway in leprosy. Nat Med 18:267-73
Parvatiyar, Kislay; Zhang, Zhiqiang; Teles, Rosane M et al. (2012) The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response. Nat Immunol 13:1155-61
Ouyang, Songying; Song, Xianqiang; Wang, Yaya et al. (2012) Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding. Immunity 36:1073-86

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