Abstract

See Abstract

Public Health Relevance

This study will examine the immediate immune responses that are generated when someone becomes infected with HIV. Through recruitment of persons with acute HIV infection, we will study killer cell responses, viral evolution and immune escape in order to inform HIV vaccine design.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AI067073-13
Application #
9485826
Study Section
Special Emphasis Panel (NSS)
Program Officer
Mcdonald, David Joseph
Project Start
2016-06-01
Project End
2021-05-31
Budget Start
2018-06-01
Budget End
2019-05-31
Support Year
13
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code

  Publications

Dong, Krista L; Moodley, Amber; Kwon, Douglas S et al. (2018) Detection and treatment of Fiebig stage I HIV-1 infection in young at-risk women in South Africa: a prospective cohort study. Lancet HIV 5:e35-e44
Ojwach, Doty B A; MacMillan, Daniel; Reddy, Tarylee et al. (2018) Pol-Driven Replicative Capacity Impacts Disease Progression in HIV-1 Subtype C Infection. J Virol 92:
Laher, Faatima; Ranasinghe, Srinika; Porichis, Filippos et al. (2017) HIV Controllers Exhibit Enhanced Frequencies of Major Histocompatibility Complex Class II Tetramer+ Gag-Specific CD4+ T Cells in Chronic Clade C HIV-1 Infection. J Virol 91:
Kløverpris, Henrik N; Kazer, Samuel W; Mjösberg, Jenny et al. (2016) Innate Lymphoid Cells Are Depleted Irreversibly during Acute HIV-1 Infection in the Absence of Viral Suppression. Immunity 44:391-405
Jones, R Brad; Walker, Bruce D (2016) HIV-specific CD8? T cells and HIV eradication. J Clin Invest 126:455-63
Xu, George J; Kula, Tomasz; Xu, Qikai et al. (2015) Viral immunology. Comprehensive serological profiling of human populations using a synthetic human virome. Science 348:aaa0698
Chetty, Shivan; Govender, Pamla; Zupkosky, Jennifer et al. (2015) Co-infection with Mycobacterium tuberculosis impairs HIV-Specific CD8+ and CD4+ T cell functionality. PLoS One 10:e0118654
Radebe, Mopo; Gounder, Kamini; Mokgoro, Mammekwa et al. (2015) Broad and persistent Gag-specific CD8+ T-cell responses are associated with viral control but rarely drive viral escape during primary HIV-1 infection. AIDS 29:23-33
Ndhlovu, Zaza M; Kamya, Philomena; Mewalal, Nikoshia et al. (2015) Magnitude and Kinetics of CD8+ T Cell Activation during Hyperacute HIV Infection Impact Viral Set Point. Immunity 43:591-604
Mann, Jaclyn K; Chopera, Denis; Omarjee, Saleha et al. (2014) Nef-mediated down-regulation of CD4 and HLA class I in HIV-1 subtype C infection: association with disease progression and influence of immune pressure. Virology 468-470:214-25

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