Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AR018033-23
Application #
2078378
Study Section
Special Emphasis Panel (NSS)
Project Start
1978-12-01
Project End
1997-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
23
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Orthopedics
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Allen, F D; Hung, C T; Pollack, S R et al. (2000) Serum modulates the intracellular calcium response of primary cultured bone cells to shear flow. J Biomech 33:1585-91
Lorich, D G; Brighton, C T; Gupta, R et al. (1998) Biochemical pathway mediating the response of bone cells to capacitive coupling. Clin Orthop Relat Res :246-56
Reilly, T M; Seldes, R; Luchetti, W et al. (1998) Similarities in the phenotypic expression of pericytes and bone cells. Clin Orthop Relat Res :95-103
Zhuang, H; Wang, W; Seldes, R M et al. (1997) Electrical stimulation induces the level of TGF-beta1 mRNA in osteoblastic cells by a mechanism involving calcium/calmodulin pathway. Biochem Biophys Res Commun 237:225-9
Wang, W; Zhuang, H; Levitz, C L et al. (1997) The increased level of PDGF-A contributes to the increased proliferation induced by mechanical stimulation in osteoblastic cells. Biochem Mol Biol Int 43:339-46
Brighton, C T; Hunt, R M (1997) Early histologic and ultrastructural changes in microvessels of periosteal callus. J Orthop Trauma 11:244-53
Hung, C T; Allen, F D; Pollack, S R et al. (1996) What is the role of the convective current density in the real-time calcium response of cultured bone cells to fluid flow? J Biomech 29:1403-9
Brighton, C T; Fisher Jr, J R; Levine, S E et al. (1996) The biochemical pathway mediating the proliferative response of bone cells to a mechanical stimulus. J Bone Joint Surg Am 78:1337-47
Zhuang, H; Wang, W; Tahernia, A D et al. (1996) Mechanical strain-induced proliferation of osteoblastic cells parallels increased TGF-beta 1 mRNA. Biochem Biophys Res Commun 229:449-53
Hung, C T; Allen, F D; Pollack, S R et al. (1996) Intracellular Ca2+ stores and extracellular Ca2+ are required in the real-time Ca2+ response of bone cells experiencing fluid flow. J Biomech 29:1411-7

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