Abstract

The research efforts funded by this grant are directed at understanding the way in which the central nervous system controls arm movements. To accomplish this goal we have devised a series of investigations in monkeys and humans. The studies with monkeys will be directed towards ascertaining the role of proprioceptive feedback in arm trajectory formation. We plan to use animals deprived of sensory feedback (dorsal rhizotomy). In humans we will study the arm trajectory around obstacles. In addition, the role and the magnitude of coriolis forces and reactional torques will be studied.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AR026710-13
Application #
3481519
Study Section
Special Emphasis Panel (NSS)
Project Start
1980-04-01
Project End
1996-11-30
Budget Start
1992-12-01
Budget End
1993-11-30
Support Year
13
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
Massachusetts Institute of Technology
Department
Type
Schools of Arts and Sciences
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
02139

  Publications

Krebs, H I; Brashers-Krug, T; Rauch, S L et al. (1998) Robot-aided functional imaging: application to a motor learning study. Hum Brain Mapp 6:59-72
Schotland, J L; Tresch, M C (1997) Segmental and propriospinal projection systems of frog lumbar interneurons. Exp Brain Res 116:283-98
Gandolfo, F; Mussa-Ivaldi, F A; Bizzi, E (1996) Motor learning by field approximation. Proc Natl Acad Sci U S A 93:3843-6
McIntyre, J; Mussa-Ivaldi, F A; Bizzi, E (1996) The control of stable postures in the multijoint arm. Exp Brain Res 110:248-64
Mussa-Ivaldi, F A; Giszter, S F; Bizzi, E (1994) Linear combinations of primitives in vertebrate motor control. Proc Natl Acad Sci U S A 91:7534-8
Shadmehr, R; Mussa-Ivaldi, F A (1994) Adaptive representation of dynamics during learning of a motor task. J Neurosci 14:3208-24
Dornay, M; Sanger, T D (1993) Equilibrium point control of a monkey arm simulator by a fast learning tree structured artificial neural network. Biol Cybern 68:499-508
Shadmehr, R; Mussa-Ivaldi, F A; Bizzi, E (1993) Postural force fields of the human arm and their role in generating multijoint movements. J Neurosci 13:45-62
Bizzi, E (1993) Intermediate representations in the formation of arm trajectories. Curr Opin Neurobiol 3:925-31
Loeb, E P; Giszter, S F; Borghesani, P et al. (1993) Effects of dorsal root cut on the forces evoked by spinal microstimulation in the spinalized frog. Somatosens Mot Res 10:81-95

Showing the most recent 10 out of 15 publications