Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37CA016861-22
Application #
2086543
Study Section
Special Emphasis Panel (NSS)
Project Start
1978-06-01
Project End
1998-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
22
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California Davis
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
094878337
City
Davis
State
CA
Country
United States
Zip Code
95618
Marquez, Bernadette V; Beck, Heather E; Aweda, Tolulope A et al. (2012) Enhancing peptide ligand binding to vascular endothelial growth factor by covalent bond formation. Bioconjug Chem 23:1080-9
Aweda, Tolulope A; Meares, Claude F (2012) Combination of isothermal titration calorimetry and time-resolved luminescence for high affinity antibody-ligand interaction thermodynamics and kinetics. Methods 56:145-53
Aweda, Tolulope A; Eskandari, Vahid; Kukis, David L et al. (2011) New covalent capture probes for imaging and therapy, based on a combination of binding affinity and disulfide bond formation. Bioconjug Chem 22:1479-83
Aweda, Tolulope A; Beck, Heather E; Wu, Anna M et al. (2010) Rates and equilibria for probe capture by an antibody with infinite affinity. Bioconjug Chem 21:784-91
Day, Jeffrey J; Marquez, Bernadette V; Beck, Heather E et al. (2010) Chemically modified antibodies as diagnostic imaging agents. Curr Opin Chem Biol 14:803-9
Wei, Liu H; Olafsen, Tove; Radu, Caius et al. (2008) Engineered antibody fragments with infinite affinity as reporter genes for PET imaging. J Nucl Med 49:1828-35
Butlin, Nathaniel G; Meares, Claude F (2006) Antibodies with infinite affinity: origins and applications. Acc Chem Res 39:780-7
Corneillie, Todd M; Whetstone, Paul A; Meares, Claude F (2006) Irreversibly binding anti-metal chelate antibodies: Artificial receptors for pretargeting. J Inorg Biochem 100:882-90
Whetstone, Paul A; Akizawa, Hiromichi; Meares, Claude F (2004) Evaluation of cleavable (Tyr3)-octreotate derivatives for longer intracellular probe residence. Bioconjug Chem 15:647-57
Corneillie, Todd M; Lee, Kelvin C; Whetstone, Paul A et al. (2004) Irreversible engineering of the multielement-binding antibody 2D12.5 and its complementary ligands. Bioconjug Chem 15:1392-402

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