Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37CA040463-12
Application #
2090226
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1985-07-01
Project End
1998-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Washington University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Taggart, David J; Camerlengo, Terry L; Harrison, Jason K et al. (2013) A high-throughput and quantitative method to assess the mutagenic potential of translesion DNA synthesis. Nucleic Acids Res 41:e96
Song, Qian; Sherrer, Shanen M; Suo, Zucai et al. (2012) Preparation of site-specific T=mCG cis-syn cyclobutane dimer-containing template and its error-free bypass by yeast and human polymerase ?. J Biol Chem 287:8021-8
Song, Qian; Cannistraro, Vincent J; Taylor, John-Stephen (2011) Rotational position of a 5-methylcytosine-containing cyclobutane pyrimidine dimer in a nucleosome greatly affects its deamination rate. J Biol Chem 286:6329-35
Asagoshi, Kenjiro; Liu, Yuan; Masaoka, Aya et al. (2010) DNA polymerase beta-dependent long patch base excision repair in living cells. DNA Repair (Amst) 9:109-19
Brown, Jessica A; Pack, Lindsey R; Sherrer, Shanen M et al. (2010) Identification of critical residues for the tight binding of both correct and incorrect nucleotides to human DNA polymerase ?. J Mol Biol 403:505-15
Cannistraro, Vincent J; Taylor, John-Stephen A (2010) Methyl CpG binding protein 2 (MeCP2) enhances photodimer formation at methyl-CpG sites but suppresses dimer deamination. Nucleic Acids Res 38:6943-55
Su, Dian G T; Taylor, John-Stephen A; Gross, Michael L (2010) A new photoproduct of 5-methylcytosine and adenine characterized by high-performance liquid chromatography and mass spectrometry. Chem Res Toxicol 23:474-9
Su, Dian G T; Fang, Huafeng; Gross, Michael L et al. (2009) Photocrosslinking of human telomeric G-quadruplex loops by anti cyclobutane thymine dimer formation. Proc Natl Acad Sci U S A 106:12861-6
Cannistraro, Vincent J; Taylor, John-Stephen (2009) Acceleration of 5-methylcytosine deamination in cyclobutane dimers by G and its implications for UV-induced C-to-T mutation hotspots. J Mol Biol 392:1145-57
Fang, Huafeng; Taylor, John-Stephen (2008) Serial analysis of mutation spectra (SAMS): a new approach for the determination of mutation spectra of site-specific DNA damage and their sequence dependence. Nucleic Acids Res 36:6004-12

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