Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
7R37CA043342-06
Application #
3482549
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1986-12-01
Project End
1993-05-31
Budget Start
1991-12-01
Budget End
1993-05-31
Support Year
6
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Thomas Jefferson University
Department
Type
Schools of Medicine
DUNS #
061197161
City
Philadelphia
State
PA
Country
United States
Zip Code
19107
Anderson, L M; Koseniauskas, R; Burak, E S et al. (1992) Reduced blood clearance and increased urinary excretion of N-nitrosodimethylamine in patas monkeys exposed to ethanol or isopropyl alcohol. Cancer Res 52:1463-8
Fong, L Y; Bevill, R F; Thurmon, J C et al. (1992) DNA adduct dosimetry and DNA repair in rats and pigs given repeated doses of procarbazine under conditions of carcinogenicity and human cancer chemotherapy respectively. Carcinogenesis 13:2153-9
Burak, E S; Harrington, G W; Koseniauskas, R et al. (1991) Estimation of the fraction of the dose of N-nitrosodimethylamine metabolized to methylamine in rats. Cancer Lett 58:1-6
Eshraghi, J; Longo, J; Dalton, D R et al. (1990) An unusual ring contraction in the formation of N-nitrosohexamethyleneimine and N-nitrosopiperidine from tolazamide. Jpn J Cancer Res 81:324-6
Harrington, G W; Magee, P N; Pylypiw Jr, H M et al. (1990) The formation, disposition, and hepatic metabolism of dimethylnitrosamine in the pig. Drug Metab Dispos 18:626-31
Gombar, C T; Harrington, G W; Pylypiw Jr, H M et al. (1990) Interspecies scaling of the pharmacokinetics of N-nitrosodimethylamine. Cancer Res 50:4366-70
Gombar, C T; Harrington, G W; Pylypiw Jr, H M et al. (1988) Pharmacokinetics of N-nitrosodimethylamine in swine. Carcinogenesis 9:1351-4