Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37CA067324-03
Application #
2110973
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1994-09-15
Project End
1999-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Cleveland Clinic Lerner
Department
Type
DUNS #
017730458
City
Cleveland
State
OH
Country
United States
Zip Code
44195
Peng, L; Kjaergaard, J; Plautz, G E et al. (2000) Helper-independent, L-selectinlow CD8+ T cells with broad anti-tumor efficacy are naturally sensitized during tumor progression. J Immunol 165:5738-49
Peng, L; Krauss, J C; Plautz, G E et al. (2000) T cell-mediated tumor rejection displays diverse dependence upon perforin and IFN-gamma mechanisms that cannot be predicted from in vitro T cell characteristics. J Immunol 165:7116-24
Kjaergaard, J; Tanaka, J; Kim, J A et al. (2000) Therapeutic efficacy of OX-40 receptor antibody depends on tumor immunogenicity and anatomic site of tumor growth. Cancer Res 60:5514-21
Mukai, S; Kagamu, H; Shu, S et al. (1999) Critical role of CD11a (LFA-1) in therapeutic efficacy of systemically transferred antitumor effector T cells. Cell Immunol 192:122-32
Kjaergaard, J; Shu, S (1999) Tumor infiltration by adoptively transferred T cells is independent of immunologic specificity but requires down-regulation of L-selectin expression. J Immunol 163:751-9
Liu, J; Finke, J; Krauss, J C et al. (1998) Ex vivo activation of tumor-draining lymph node T cells reverses defects in signal transduction molecules. Cancer Immunol Immunother 46:268-76
Wang, J; Saffold, S; Cao, X et al. (1998) Eliciting T cell immunity against poorly immunogenic tumors by immunization with dendritic cell-tumor fusion vaccines. J Immunol 161:5516-24
Peng, L; Shu, S; Krauss, J C (1997) Monocyte chemoattractant protein inhibits the generation of tumor-reactive T cells. Cancer Res 57:4849-54
Peng, L; Shu, S; Krauss, J C (1997) Treatment of subcutaneous tumor with adoptively transferred T cells. Cell Immunol 178:24-32
Krauss, J C; Shu, S (1997) Secretion of biologically active superantigens by mammalian cells. J Hematother 6:41-51

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