This proposal is a REQUEST FOR EXTENSION OF MERIT AWARD for R37 DA015969) Computer Based Training in Cognitive Behavioral Therapy: A Stage I Trial of """"""""CBT 4 CBT"""""""". During the past 3 years, we have completed the computer-assisted training program and are on track to complete the randomized trial evaluating this approach within a community-based substance abuse setting as described in the original specific aims. We have also initiated a comprehensive neurocognitive battery and functional MRI scanning for all eligible participants in the randomized trial, in order to evaluate neurobiological possible correlates of response to CBT. For the extension period, we propose to (1) add one additional module to the existing CBT4CBT program, drawn from the NIDA CBT manual, that will address HIV risk behaviors, (2) expand patient diversity and evaluate the efficacy of the CBT4CBT program with the new HIV module by conducting a new parallel randomized trial with 80 drug -using individuals maintained on methadone who are at risk for HIV, (3) extend the neurocognitive and neuroimaging components currently funded by a supplement to the R37 to the proposed new methadone trial, and (4) add a novel behavioral genetics study that will evaluate the extent to which individuals with the COMT Met/Met versus the ValA/al genotype predict response to CBT.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37DA015969-06
Application #
7293516
Study Section
Special Emphasis Panel (NSS)
Program Officer
Mcnamara-Spitznas, Cecilia M
Project Start
2002-09-30
Project End
2010-05-31
Budget Start
2007-06-01
Budget End
2008-05-31
Support Year
6
Fiscal Year
2007
Total Cost
$353,647
Indirect Cost
Name
Yale University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Kiluk, Brian D; Nich, Charla; Buck, Matthew B et al. (2018) Randomized Clinical Trial of Computerized and Clinician-Delivered CBT in Comparison With Standard Outpatient Treatment for Substance Use Disorders: Primary Within-Treatment and Follow-Up Outcomes. Am J Psychiatry 175:853-863
Paris, Manuel; Silva, Michelle; AƱez-Nava, Luis et al. (2018) Culturally Adapted, Web-Based Cognitive Behavioral Therapy for Spanish-Speaking Individuals With Substance Use Disorders: A Randomized Clinical Trial. Am J Public Health 108:1535-1542
DeVito, Elise E; Kiluk, Brian D; Nich, Charla et al. (2018) Drug Stroop: Mechanisms of response to computerized cognitive behavioral therapy for cocaine dependence in a randomized clinical trial. Drug Alcohol Depend 183:162-168
Decker, Suzanne E; Morie, Kristen P; Malin-Mayo, Bo et al. (2018) Positive and negative affect in cocaine use disorder treatment: Change across time and relevance to treatment outcome. Am J Addict :
Carroll, Kathleen M; Nich, Charla; DeVito, Elise E et al. (2018) Galantamine and Computerized Cognitive Behavioral Therapy for Cocaine Dependence: A Randomized Clinical Trial. J Clin Psychiatry 79:
Carroll, Kathleen M; Kiluk, Brian D (2017) Cognitive behavioral interventions for alcohol and drug use disorders: Through the stage model and back again. Psychol Addict Behav 31:847-861
Serafini, Kelly; Kiluk, Brian D; Babuscio, Theresa et al. (2016) Patient Pre-Treatment Expectations Do Not Predict Cocaine Use Outcomes: Data From Four Clinical Trials. Subst Use Misuse 51:1484-92
Morie, Kristen P; Yip, Sarah W; Nich, Charla et al. (2016) Alexithymia and Addiction: A Review and Preliminary Data Suggesting Neurobiological Links to Reward/Loss Processing. Curr Addict Rep 3:239-248
Yip, Sarah W; DeVito, Elise E; Kober, Hedy et al. (2016) Anticipatory reward processing among cocaine-dependent individuals with and without concurrent methadone-maintenance treatment: Relationship to treatment response. Drug Alcohol Depend 166:134-42
Morie, Kristen P; Nich, Charla; Hunkele, Karen et al. (2015) Alexithymia level and response to computer-based training in cognitive behavioral therapy among cocaine-dependent methadone maintained individuals. Drug Alcohol Depend 152:157-63

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