Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37DK009765-30
Application #
2136634
Study Section
Special Emphasis Panel (NSS)
Project Start
1977-12-01
Project End
1996-11-30
Budget Start
1994-12-01
Budget End
1996-11-30
Support Year
30
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of California Berkeley
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
094878337
City
Berkeley
State
CA
Country
United States
Zip Code
94704
Cheever, L; Koshland Jr, D E (1994) Habituation of neurosecretory responses to extracellular ATP in PC12 cells. J Neurosci 14:4831-8
Danielson, M A; Biemann, H P; Koshland Jr, D E et al. (1994) Attractant- and disulfide-induced conformational changes in the ligand binding domain of the chemotaxis aspartate receptor: a 19F NMR study. Biochemistry 33:6100-9
Jeffery, C J; Koshland Jr, D E (1994) A single hydrophobic to hydrophobic substitution in the transmembrane domain impairs aspartate receptor function. Biochemistry 33:3457-63
Biemann, H P; Koshland Jr, D E (1994) Aspartate receptors of Escherichia coli and Salmonella typhimurium bind ligand with negative and half-of-the-sites cooperativity. Biochemistry 33:629-34
Shapiro, M J; Koshland Jr, D E (1994) Mutagenic studies of the interaction between the aspartate receptor and methyltransferase from Escherichia coli. J Biol Chem 269:11054-9
Morimoto, B H; Koshland Jr, D E (1994) Conditional activation of cAMP signal transduction by protein kinase C. The effect of phorbol esters on adenylyl cyclase in permeabilized and intact cells. J Biol Chem 269:4065-9
Jeffery, C J; Koshland Jr, D E (1993) Three-dimensional structural model of the serine receptor ligand-binding domain. Protein Sci 2:559-66
Yeh, J I; Biemann, H P; Pandit, J et al. (1993) The three-dimensional structure of the ligand-binding domain of a wild-type bacterial chemotaxis receptor. Structural comparison to the cross-linked mutant forms and conformational changes upon ligand binding. J Biol Chem 268:9787-92
Stoddard, B L; Koshland Jr, D E (1993) Molecular recognition analyzed by docking simulations: the aspartate receptor and isocitrate dehydrogenase from Escherichia coli. Proc Natl Acad Sci U S A 90:1146-53
Martin, P T; Chung, B T; Koshland Jr, D E (1993) Regulation of neurosecretory habituation by cAMP. Role of adaptation of cAMP signals. Eur J Biochem 217:259-65

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