Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37DK020043-18
Application #
2137432
Study Section
Pathology A Study Section (PTHA)
Project Start
1977-04-01
Project End
1999-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
18
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Fujinaka, H; Yamamoto, T; Feng, L et al. (2007) Anti-perforin antibody treatment ameliorates experimental crescentic glomerulonephritis in WKY rats. Kidney Int 72:823-30
Narsipur, Sriram S; Peterson, Orjan W; Smith, Robert et al. (2003) Mechanisms of glomerular immune injury: effects of antioxidant treatment. J Am Soc Nephrol 14:1748-55
Garcia, Gabriela E; Xia, Yiyang; Ku, George et al. (2003) IL-18 translational inhibition restricts IFN-gamma expression in crescentic glomerulonephritis. Kidney Int 64:160-9
Garcia, Gabriela E; Xia, Yiyang; Harrison, Jeffrey et al. (2003) Mononuclear cell-infiltrate inhibition by blocking macrophage-derived chemokine results in attenuation of developing crescentic glomerulonephritis. Am J Pathol 162:1061-73
Tang, W W; Feng, L; Loskutoff, D J et al. (2000) Glomerular extracellular matrix accumulation in experimental anti-GBM Ab glomerulonephritis. Nephron 84:40-8
Feng, L; Garcia, G E; Yang, Y et al. (2000) Heparin-binding EGF-like growth factor contributes to reduced glomerular filtration rate during glomerulonephritis in rats. J Clin Invest 105:341-50
Feng, L; Chen, S; Garcia, G E et al. (1999) Prevention of crescentic glomerulonephritis by immunoneutralization of the fractalkine receptor CX3CR1 rapid communication. Kidney Int 56:612-20
Hirose, S; Yamamoto, T; Feng, L et al. (1998) Expression and localization of cyclooxygenase isoforms and cytosolic phospholipase A2 in anti-Thy-1 glomerulonephritis. J Am Soc Nephrol 9:408-16
Schwartz, D; Mendonca, M; Schwartz, I et al. (1997) Inhibition of constitutive nitric oxide synthase (NOS) by nitric oxide generated by inducible NOS after lipopolysaccharide administration provokes renal dysfunction in rats. J Clin Invest 100:439-48
Fujinaka, H; Yamamoto, T; Feng, L et al. (1997) Crucial role of CD8-positive lymphocytes in glomerular expression of ICAM-1 and cytokines in crescentic glomerulonephritis of WKY rats. J Immunol 158:4978-83

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