Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
3R37DK030312-13S1
Application #
2138355
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1982-02-01
Project End
1997-01-31
Budget Start
1994-09-20
Budget End
1995-01-31
Support Year
13
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of Southern California
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Han, Derick; Hanawa, Naoko; Saberi, Behnam et al. (2006) Hydrogen peroxide and redox modulation sensitize primary mouse hepatocytes to TNF-induced apoptosis. Free Radic Biol Med 41:627-39
Liu, Zhang-Xu; Han, Derick; Gunawan, Basuki et al. (2006) Neutrophil depletion protects against murine acetaminophen hepatotoxicity. Hepatology 43:1220-30
Gunawan, Basuki K; Liu, Zhang-Xu; Han, Derick et al. (2006) c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity. Gastroenterology 131:165-78
Liu, Zhang-Xu; Govindarajan, Sugantha; Kaplowitz, Neil (2004) Innate immune system plays a critical role in determining the progression and severity of acetaminophen hepatotoxicity. Gastroenterology 127:1760-74
Mittur, Aravind; Wolkoff, Allan W; Kaplowitz, Neil (2002) The thiol sensitivity of glutathione transport in sidedness-sorted basolateral liver plasma membrane and in Oatp1-expressing HeLa cell membrane. Mol Pharmacol 61:425-35
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Mittur, A V; Kaplowitz, N; Kempner, E S et al. (1998) Novel properties of hepatic canalicular reduced glutathione transport revealed by radiation inactivation. Am J Physiol 274:G923-30
Lu, S C; Kuhlenkamp, J; Wu, H et al. (1997) Progressive defect in biliary GSH secretion in streptozotocin-induced diabetic rats. Am J Physiol 272:G374-82
Fernandez-Checa, J C; Yi, J R; Garcia Ruiz, C et al. (1996) Plasma membrane and mitochondrial transport of hepatic reduced glutathione. Semin Liver Dis 16:147-58

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