Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37DK030399-20
Application #
6846427
Study Section
Special Emphasis Panel (NSS)
Program Officer
Hamilton, Frank A
Project Start
1982-08-01
Project End
2009-03-31
Budget Start
2004-05-21
Budget End
2005-03-31
Support Year
20
Fiscal Year
2004
Total Cost
$394,172
Indirect Cost
Name
Case Western Reserve University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
de Souza, Heitor S P; West, Gail A; Rebert, Nancy et al. (2012) Increased levels of survivin, via association with heat shock protein 90, in mucosal T cells from patients with Crohn's disease. Gastroenterology 143:1017-26.e9
Angulo, Sandra; Morales, Albert; Danese, Silvio et al. (2011) Probiotic sonicates selectively induce mucosal immune cells apoptosis through ceramide generation via neutral sphingomyelinase. PLoS One 6:e16953
Sturm, Andreas; de Souza, Heitor S P; Fiocchi, Claudio (2008) Mucosal T cell proliferation and apoptosis in inflammatory bowel disease. Curr Drug Targets 9:381-7
Danese, Silvio; Sans, Miquel; Spencer, David M et al. (2007) Angiogenesis blockade as a new therapeutic approach to experimental colitis. Gut 56:855-62
Kugathasan, S; Saubermann, L J; Smith, L et al. (2007) Mucosal T-cell immunoregulation varies in early and late inflammatory bowel disease. Gut 56:1696-705
Sans, Miquel; Danese, Silvio; de la Motte, Carol et al. (2007) Enhanced recruitment of CX3CR1+ T cells by mucosal endothelial cell-derived fractalkine in inflammatory bowel disease. Gastroenterology 132:139-53
Rieder, Florian; Cheng, Ling; Harnett, Karen M et al. (2007) Gastroesophageal reflux disease-associated esophagitis induces endogenous cytokine production leading to motor abnormalities. Gastroenterology 132:154-65
Danese, Silvio; Dejana, Elisabetta; Fiocchi, Claudio (2007) Immune regulation by microvascular endothelial cells: directing innate and adaptive immunity, coagulation, and inflammation. J Immunol 178:6017-22
Danese, Silvio; Sans, Miquel; de la Motte, Carol et al. (2006) Angiogenesis as a novel component of inflammatory bowel disease pathogenesis. Gastroenterology 130:2060-73
Danese, Silvio; Fiocchi, Claudio (2005) Platelet activation and the CD40/CD40 ligand pathway: mechanisms and implications for human disease. Crit Rev Immunol 25:103-21

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