Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37DK031405-32
Application #
8477172
Study Section
Special Emphasis Panel (NSS)
Program Officer
Haft, Carol R
Project Start
1982-07-01
Project End
2014-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
32
Fiscal Year
2013
Total Cost
$660,464
Indirect Cost
$254,101

  Institution

Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
076580745
City
Boston
State
MA
Country
United States
Zip Code
02215

  Publications

Khandekar, Melin J; Banks, Alexander S; Laznik-Bogoslavski, Dina et al. (2018) Noncanonical agonist PPAR? ligands modulate the response to DNA damage and sensitize cancer cells to cytotoxic chemotherapy. Proc Natl Acad Sci U S A 115:561-566
Long, Jonathan Z; Roche, Alexander M; Berdan, Charles A et al. (2018) Ablation of PM20D1 reveals N-acyl amino acid control of metabolism and nociception. Proc Natl Acad Sci U S A 115:E6937-E6945
Chouchani, Edward T; Kazak, Lawrence; Spiegelman, Bruce M (2017) Mitochondrial reactive oxygen species and adipose tissue thermogenesis: Bridging physiology and mechanisms. J Biol Chem 292:16810-16816
Kazak, Lawrence; Chouchani, Edward T; Lu, Gina Z et al. (2017) Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity. Cell Metab 26:660-671.e3
Chen, Yi; Zeng, Xing; Huang, Xuan et al. (2017) Crosstalk between KCNK3-Mediated Ion Current and Adrenergic Signaling Regulates Adipose Thermogenesis and Obesity. Cell 171:836-848.e13
Bertholet, Ambre M; Kazak, Lawrence; Chouchani, Edward T et al. (2017) Mitochondrial Patch Clamp of Beige Adipocytes Reveals UCP1-Positive and UCP1-Negative Cells Both Exhibiting Futile Creatine Cycling. Cell Metab 25:811-822.e4
Kir, Serkan; Komaba, Hirotaka; Garcia, Ana P et al. (2016) PTH/PTHrP Receptor Mediates Cachexia in Models of Kidney Failure and Cancer. Cell Metab 23:315-23
Long, Jonathan Z; Svensson, Katrin J; Bateman, Leslie A et al. (2016) The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of Mitochondria. Cell 166:424-435
Chouchani, Edward T; Kazak, Lawrence; Jedrychowski, Mark P et al. (2016) Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1. Nature 532:112-6
Zeng, Xing; Jedrychowski, Mark P; Chen, Yi et al. (2016) Lysine-specific demethylase 1 promotes brown adipose tissue thermogenesis via repressing glucocorticoid activation. Genes Dev 30:1822-36

Showing the most recent 10 out of 95 publications