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Williams, Lakenya; Fresquet, Vicente; Santander, Patricio J et al. (2007) The multiple amidation reactions catalyzed by Cobyric acid synthetase from Salmonella typhimurium are sequential and dissociative. J Am Chem Soc 129:294-5
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Kajiwara, Yasuhiro; Santander, Patricio J; Roessner, Charles A et al. (2006) Genetically engineered synthesis and structural characterization of cobalt-precorrin 5A and -5B, two new intermediates on the anaerobic pathway to vitamin B12: definition of the roles of the CbiF and CbiG enzymes. J Am Chem Soc 128:9971-8
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Santander, Patricio J; Kajiwara, Yasuhiro; Williams, Howard J et al. (2006) Structural characterization of novel cobalt corrinoids synthesized by enzymes of the vitamin B12 anaerobic pathway. Bioorg Med Chem 14:724-31
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Roessner, Charles A; Scott, A Ian (2006) Fine-tuning our knowledge of the anaerobic route to cobalamin (vitamin B12). J Bacteriol 188:7331-4
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Chow, Siew Yin; Williams, Howard J; Huang, Qiulong et al. (2005) Studies on taxadiene synthase: interception of the cyclization cascade at the isocembrene stage with GGPP analogues. J Org Chem 70:9997-10003
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Roessner, Charles A; Williams, Howard J; Scott, A Ian (2005) Genetically engineered production of 1-desmethylcobyrinic acid, 1-desmethylcobyrinic acid a,c-diamide, and cobyrinic acid a,c-diamide in Escherichia coli implies a role for CbiD in C-1 methylation in the anaerobic pathway to cobalamin. J Biol Chem 280:16748-53
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Roessner, Charles A; Ponnamperuma, Krishan; Scott, A I (2002) Mutagenesis identifies a conserved tyrosine residue important for the activity of uroporphyrinogen III synthase from Anacystis nidulans. FEBS Lett 525:25-8
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Roessner, C A; Santander, P J; Scott, A I (2001) Multiple biosynthetic pathways for vitamin B12: variations on a central theme. Vitam Horm 61:267-97
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Santander, P J; Stolowich, N J; Scott, A I (1999) Chemoenzymatic synthesis of an unnatural tetramethyl cobalt corphinoid. Bioorg Med Chem 7:789-94
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Spencer, P; Stolowich, N J; Sumner, L W et al. (1998) Definition of the redox states of cobalt-precorrinoids: investigation of the substrate and redox specificity of CbiL from Salmonella typhimurium. Biochemistry 37:14917-27
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