Activation of the Alternative Pathway of Complement

Pangburn, Michael K.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Method to Extend Research in Time (MERIT) Award (R37)
• Project #: 5R37DK035081-12
• Application #: 2139470
• Study Section: Allergy and Immunology Study Section (ALY)
• Project Start: 1984-09-01
• Project End: 1998-02-28
• Budget Start: 1996-03-01
• Budget End: 1997-02-28
• Support Year: 12
• Fiscal Year: 1996

Institution

• Name: University of Texas Health Center at Tyler
• Department: Biochemistry
• Type: Other Domestic Higher Education
• City: Tyler
• State: TX
• Country: United States
• Zip Code: 75708

Publications

Ferreira, Viviana P; Fazito Vale, Vladimir; Pangburn, Michael K et al. (2016) SALO, a novel classical pathway complement inhibitor from saliva of the sand fly Lutzomyia longipalpis. Sci Rep 6:19300

Takeda, Katsuyuki; Thurman, Joshua M; Tomlinson, Stephen et al. (2012) The critical role of complement alternative pathway regulator factor H in allergen-induced airway hyperresponsiveness and inflammation. J Immunol 188:661-7

Renner, Brandon; Ferreira, Viviana P; Cortes, Claudio et al. (2011) Binding of factor H to tubular epithelial cells limits interstitial complement activation in ischemic injury. Kidney Int 80:165-73

Cortes, Claudio; Ferreira, V P; Pangburn, Michael K (2011) Native properdin binds to Chlamydia pneumoniae and promotes complement activation. Infect Immun 79:724-31

Ferreira, Viviana P; Pangburn, Michael K; Cortes, Claudio (2010) Complement control protein factor H: the good, the bad, and the inadequate. Mol Immunol 47:2187-97

Renner, Brandon; Coleman, Kathrin; Goldberg, Ryan et al. (2010) The complement inhibitors Crry and factor H are critical for preventing autologous complement activation on renal tubular epithelial cells. J Immunol 185:3086-94

Rohrer, Bärbel; Long, Qin; Coughlin, Beth et al. (2010) A targeted inhibitor of the complement alternative pathway reduces RPE injury and angiogenesis in models of age-related macular degeneration. Adv Exp Med Biol 703:137-49

Agarwal, Sarika; Ferreira, Viviana P; Cortes, Claudio et al. (2010) An evaluation of the role of properdin in alternative pathway activation on Neisseria meningitidis and Neisseria gonorrhoeae. J Immunol 185:507-16

Ferreira, Viviana P; Cortes, Claudio; Pangburn, Michael K (2010) Native polymeric forms of properdin selectively bind to targets and promote activation of the alternative pathway of complement. Immunobiology 215:932-40

Thurman, Joshua M; Renner, Brandon; Kunchithapautham, Kannan et al. (2010) Aseptic injury to epithelial cells alters cell surface complement regulation in a tissue specific fashion. Adv Exp Med Biol 664:151-8