Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
3R37DK035158-05S1
Application #
3483681
Study Section
Metabolism Study Section (MET)
Project Start
1984-07-01
Project End
1990-12-31
Budget Start
1988-07-01
Budget End
1988-12-31
Support Year
5
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Sloan-Kettering Institute for Cancer Research
Department
Type
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10065
Ahn, J; Rosen, O M; Donner, D B (1993) Human insulin receptor mutated at threonine 1336 functions normally in Chinese hamster ovary cells. J Biol Chem 268:16839-44
Ahn, J; Donner, D B; Rosen, O M (1993) Interaction of the human insulin receptor tyrosine kinase from the baculovirus expression system with protein kinase C in a cell-free system. J Biol Chem 268:7571-6
Murakami, M S; Rosen, O M (1991) The role of insulin receptor autophosphorylation in signal transduction. J Biol Chem 266:22653-60
Vera, J C; Castillo, G R; Rosen, O M (1991) A possible role for a mammalian facilitative hexose transporter in the development of resistance to drugs. Mol Cell Biol 11:3407-18
Rapuano, M; Rosen, O M (1991) Phosphorylation of the insulin receptor by a casein kinase I-like enzyme. J Biol Chem 266:12902-7
Castillo, G; Vera, J C; Yang, C P et al. (1990) Functional expression of murine multidrug resistance in Xenopus laevis oocytes. Proc Natl Acad Sci U S A 87:4737-41
Fischbarg, J; Kuang, K Y; Vera, J C et al. (1990) Glucose transporters serve as water channels. Proc Natl Acad Sci U S A 87:3244-7
Vera, J C; Rosen, O M (1990) Reconstitution of an insulin signaling pathway in Xenopus laevis oocytes: coexpression of a mammalian insulin receptor and three different mammalian hexose transporters. Mol Cell Biol 10:743-51
Villalba, M; Alvarez, J F; Russell, D S et al. (1990) Hydrolysis of glycosyl-phosphatidylinositol in response to insulin is reduced in cells bearing kinase-deficient insulin receptors. Growth Factors 2:91-7
Makowske, M; Rosen, O M (1989) Complete activation of protein kinase C by an antipeptide antibody directed against the pseudosubstrate prototope. J Biol Chem 264:16155-9

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