Glutamine Amidotransferases and Partner Enzymes

Agency: National Institute of Health (NIH)
Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type: Method to Extend Research in Time (MERIT) Award (R37)
Project #: 5R37DK042303-15
Application #: 6700304
Study Section: Special Emphasis Panel (NSS)
Program Officer: Sechi, Salvatore


NIH 2007 R37 DK	Glutamine Amidotransferases and Partner Enzymes Smith, Janet L. / University of Michigan Ann Arbor	$379,807
NIH 2006 R37 DK	Glutamine Amidotransferases and Partner Enzymes Smith, Janet L. / University of Michigan Ann Arbor	$381,613
NIH 2005 R37 DK	Glutamine Amidotransferases and Partner Enzymes Smith, Janet L. / University of Michigan Ann Arbor	$367,356
NIH 2004 R37 DK	Glutamine Amidotransferases and Partner Enzymes Smith, Janet L. / Purdue University	$142,013
NIH 2003 R37 DK	Glutamine Amidotransferases and Partner Enzymes Smith, Janet L. / Purdue University	$356,031
NIH 2002 R37 DK	Glutamine Amidotransferases and Partner Enzymes Smith, Janet L. / Purdue University	$248,753
NIH 2001 R37 DK	Glutamine Amidotransferases and Partner Enzymes Smith, Janet L. / Purdue University	$241,505
NIH 2000 R37 DK	Glutamine Amidotransferases and Partner Enzymes Smith, Janet L. / Purdue University	$234,472
NIH 1999 R37 DK	Glutamine Amidotransferases and Partner Enzymes Smith, Janet L. / Purdue University
NIH 1998 R37 DK	Glutamine Amidotransferases and Partner Enzymes Smith, Janet L. / Purdue University

Skiba, Meredith A; Sikkema, Andrew P; Moss, Nathan A et al. (2018) Biosynthesis of t-Butyl in Apratoxin A: Functional Analysis and Architecture of a PKS Loading Module. ACS Chem Biol 13:1640-1650

Dodge, Greg J; Maloney, Finn P; Smith, Janet L (2018) Protein-protein interactions in ""cis-AT"" polyketide synthases. Nat Prod Rep 35:1082-1096

Dodge, Greg J; Ronnow, Danialle; Taylor, Richard E et al. (2018) Molecular Basis for Olefin Rearrangement in the Gephyronic Acid Polyketide Synthase. ACS Chem Biol 13:2699-2707

Skiba, Meredith A; Sikkema, Andrew P; Fiers, William D et al. (2016) Domain Organization and Active Site Architecture of a Polyketide Synthase C-methyltransferase. ACS Chem Biol 11:3319-3327

Khare, Dheeraj; Hale, Wendi A; Tripathi, Ashootosh et al. (2015) Structural Basis for Cyclopropanation by a Unique Enoyl-Acyl Carrier Protein Reductase. Structure 23:2213-2223

Smith, Amber Marie; Brown, William Clay; Harms, Etti et al. (2015) Crystal structures capture three states in the catalytic cycle of a pyridoxal phosphate (PLP) synthase. J Biol Chem 290:5226-39

Bernard, Steffen M; Akey, David L; Tripathi, Ashootosh et al. (2015) Structural basis of substrate specificity and regiochemistry in the MycF/TylF family of sugar O-methyltransferases. ACS Chem Biol 10:1340-51

Smith, Janet L; Skiniotis, Georgios; Sherman, David H (2015) Architecture of the polyketide synthase module: surprises from electron cryo-microscopy. Curr Opin Struct Biol 31:9-19

Dutta, Somnath; Whicher, Jonathan R; Hansen, Douglas A et al. (2014) Structure of a modular polyketide synthase. Nature 510:512-7

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