Regulation of Extracellular Matrix in Kidney Disease

Border, Wayne A.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Method to Extend Research in Time (MERIT) Award (R37)
• Project #: 4R37DK043609-15
• Application #: 6864402
• Study Section: Special Emphasis Panel (NSS)
• Program Officer: Ketchum, Christian J
• Project Start: 1990-09-30
• Project End: 2009-08-31
• Budget Start: 2004-09-01
• Budget End: 2005-08-31
• Support Year: 15
• Fiscal Year: 2004
• Total Cost: $516,662

Institution

• Name: University of Utah
• Department: Internal Medicine/Medicine
• Type: Schools of Medicine
• DUNS #: 009095365
• City: Salt Lake City
• State: UT
• Country: United States
• Zip Code: 84112

Publications

Zhang, Jiandong; Wu, Jie; Gu, Chunyan et al. (2012) Receptor-mediated nonproteolytic activation of prorenin and induction of TGF-ýý1 and PAI-1 expression in renal mesangial cells. Am J Physiol Renal Physiol 303:F11-20

Zhang, Jiandong; Gu, Chunyan; Noble, Nancy A et al. (2011) Combining angiotensin II blockade and renin receptor inhibition results in enhanced antifibrotic effect in experimental nephritis. Am J Physiol Renal Physiol 301:F723-32

Zhang, Jiandong; Noble, Nancy A; Border, Wayne A et al. (2010) Infusion of angiotensin-(1-7) reduces glomerulosclerosis through counteracting angiotensin II in experimental glomerulonephritis. Am J Physiol Renal Physiol 298:F579-88

Huang, Yufeng; Border, Wayne A; Lawrence, Daniel A et al. (2009) Mechanisms underlying the antifibrotic properties of noninhibitory PAI-1 (PAI-1R) in experimental nephritis. Am J Physiol Renal Physiol 297:F1045-54

Zhang, Jiandong; Noble, Nancy A; Border, Wayne A et al. (2008) Receptor-dependent prorenin activation and induction of PAI-1 expression in vascular smooth muscle cells. Am J Physiol Endocrinol Metab 295:E810-9

Huang, Wei; Xu, Chen; Kahng, Kyoung W et al. (2008) Aldosterone and TGF-beta1 synergistically increase PAI-1 and decrease matrix degradation in rat renal mesangial and fibroblast cells. Am J Physiol Renal Physiol 294:F1287-95

Huang, Yufeng; Noble, Nancy A (2007) PAI-1 as a target in kidney disease. Curr Drug Targets 8:1007-15

Huang, Y; Noble, N A; Zhang, J et al. (2007) Renin-stimulated TGF-beta1 expression is regulated by a mitogen-activated protein kinase in mesangial cells. Kidney Int 72:45-52

Huang, Y; Border, W A; Lawrence, D A et al. (2006) Noninhibitory PAI-1 enhances plasmin-mediated matrix degradation both in vitro and in experimental nephritis. Kidney Int 70:515-22

Huang, Y; Wongamorntham, S; Kasting, J et al. (2006) Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms. Kidney Int 69:105-13