III. Abstract of Research Plan for Extension Period (5 years) 1. To examine the role of co-repressors, e.g., HDAC, Sin3A, in menin-mediated inhibition of gastrin 2. To examine the role of somatostatin in regulation of co-repressors 3. To determine the role of somatostatin and menin in the regulation of p27 and cell proliferation. Role of MLL. Are duodenal gastrinomas of myeloid origin?
Relevance to publish health include furthering our understanding of peptic ulcer disease, neuroendocrine transformation and the molecular basis underlying the effects of SOM analogs used to treat neuroendocrine disorders.
| Wang, Zhen; Ocadiz-Ruiz, Ramon; Sundaresan, Sinju et al. (2018) Isolation of Enteric Glial Cells from the Submucosa and Lamina Propria of the Adult Mouse. J Vis Exp : |
| Saqui-Salces, Milena; Tsao, Amy C; Gillilland 3rd, Merritt G et al. (2017) Weight gain in mice on a high caloric diet and chronically treated with omeprazole depends on sex and genetic background. Am J Physiol Gastrointest Liver Physiol 312:G15-G23 |
| Sundaresan, Sinju; Kang, Anthony J; Merchant, Juanita L (2017) Pathophysiology of Gastric NETs: Role of Gastrin and Menin. Curr Gastroenterol Rep 19:32 |
| Sundaresan, Sinju; Kang, Anthony J; Hayes, Michael M et al. (2017) Deletion of Men1 and somatostatin induces hypergastrinemia and gastric carcinoids. Gut 66:1012-1021 |
| Sahoo, Nirakar; Gu, Mingxue; Zhang, Xiaoli et al. (2017) Gastric Acid Secretion from Parietal Cells Is Mediated by a Ca2+ Efflux Channel in the Tubulovesicle. Dev Cell 41:262-273.e6 |
| Sundaresan, Sinju; Meininger, Cameron A; Kang, Anthony J et al. (2017) Gastrin Induces Nuclear Export and Proteasome Degradation of Menin in Enteric Glial Cells. Gastroenterology 153:1555-1567.e15 |
| Huang, Jing; Gurung, Buddha; Wan, Bingbing et al. (2012) The same pocket in menin binds both MLL and JUND but has opposite effects on transcription. Nature 482:542-6 |
| Saqui-Salces, Milena; Covés-Datson, Evelyn; Veniaminova, Natalia A et al. (2012) Inflammation and Gli2 suppress gastrin gene expression in a murine model of antral hyperplasia. PLoS One 7:e48039 |
| Berndt, Bradford E; Zhang, Min; Owyang, Stephanie Y et al. (2012) Butyrate increases IL-23 production by stimulated dendritic cells. Am J Physiol Gastrointest Liver Physiol 303:G1384-92 |
| Saqui-Salces, Milena; Dowdle, William E; Reiter, Jeremy F et al. (2012) A high-fat diet regulates gastrin and acid secretion through primary cilia. FASEB J 26:3127-39 |
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