Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37DK060596-17
Application #
9471818
Study Section
Special Emphasis Panel (NSS)
Program Officer
Maruvada, Padma
Project Start
2016-06-15
Project End
2021-04-30
Budget Start
2018-05-01
Budget End
2019-04-30
Support Year
17
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Genetics
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Dasarathy, Srinivasan; Hatzoglou, Maria (2018) Hyperammonemia and proteostasis in cirrhosis. Curr Opin Clin Nutr Metab Care 21:30-36
Ko, Chih-Wei; Counihan, Daniel; Wu, Jing et al. (2018) Macrophages with a deletion of the phosphoenolpyruvate carboxykinase 1 (Pck1) gene have a more proinflammatory phenotype. J Biol Chem 293:3399-3409
Dery?o, Kamil; Michalec-WawiĆ³rka, Barbara; Krokowski, Dawid et al. (2018) The uL10 protein, a component of the ribosomal P-stalk, is released from the ribosome in nucleolar stress. Biochim Biophys Acta Mol Cell Res 1865:34-47
Krishnamoorthy, Jothilatha; Tenkerian, Clara; Gupta, Jyotsana et al. (2018) Downregulation of PERK activity and eIF2? serine 51 phosphorylation by mTOR complex 1 elicits pro-oxidant and pro-death effects in tuberous sclerosis-deficient cells. Cell Death Dis 9:254
Yadav, Vinita; Gao, Xing-Huang; Willard, Belinda et al. (2017) Hydrogen sulfide modulates eukaryotic translation initiation factor 2? (eIF2?) phosphorylation status in the integrated stress-response pathway. J Biol Chem 292:13143-13153
Roy, Debasish; Farabaugh, Kenneth T; Wu, Jing et al. (2017) Coordinated transcriptional control of adipocyte triglyceride lipase (Atgl) by transcription factors Sp1 and peroxisome proliferator-activated receptor ? (PPAR?) during adipocyte differentiation. J Biol Chem 292:14827-14835
Krokowski, Dawid; Guan, Bo-Jhih; Wu, Jing et al. (2017) GADD34 Function in Protein Trafficking Promotes Adaptation to Hyperosmotic Stress in Human Corneal Cells. Cell Rep 21:2895-2910
Choi, Woo-Gyun; Han, Jaeseok; Kim, Ji-Hyeon et al. (2017) eIF2? phosphorylation is required to prevent hepatocyte death and liver fibrosis in mice challenged with a high fructose diet. Nutr Metab (Lond) 14:48
Ziosi, Marcello; Di Meo, Ivano; Kleiner, Giulio et al. (2017) Coenzyme Q deficiency causes impairment of the sulfide oxidation pathway. EMBO Mol Med 9:96-111
Guan, Bo-Jhih; van Hoef, Vincent; Jobava, Raul et al. (2017) A Unique ISR Program Determines Cellular Responses to Chronic Stress. Mol Cell 68:885-900.e6

Showing the most recent 10 out of 40 publications