Recent advances in experimental methods, such as microarrays, fMRI imaging, and protein spectroscopy, have vastly increased the size and scope of biomedical data analyses. This has challenged traditional statistical theory, which was mainly developed to deal with small """"""""one-at-a-time"""""""" problems. New statistical methodology is being invented, and the purpose here is to bring these developments to bear on massively parallel data sets such as those produced in microarray experiments. Two complementary aspects of statistical inference in large data sets will be attacked; identifying individually significant cases (e.g. genes), among hundreds or thousands of possibilities and identifying groups of cases that work together to influence disease etiology.
| Efron, Bradley (2015) Frequentist accuracy of Bayesian estimates. J R Stat Soc Series B Stat Methodol 77:617-646 |
| Efron, Bradley (2014) Two modeling strategies for empirical Bayes estimation. Stat Sci 29:285-301 |
| Efron, Bradley (2014) Estimation and Accuracy after Model Selection. J Am Stat Assoc 109:991-1007 |
| Yoon, Sangho; Assimes, Themistocles L; Quertermous, Thomas et al. (2014) Insulin resistance: regression and clustering. PLoS One 9:e94129 |
| Won, Joong-Ho; Lim, Johan; Kim, Seung-Jean et al. (2013) Condition Number Regularized Covariance Estimation. J R Stat Soc Series B Stat Methodol 75:427-450 |
| Olshen, Adam B; Hsieh, Andrew C; Stumpf, Craig R et al. (2013) Assessing gene-level translational control from ribosome profiling. Bioinformatics 29:2995-3002 |
| Efron, Bradley (2013) Mathematics. Bayes' theorem in the 21st century. Science 340:1177-8 |
| Smith, Roger S; Efron, Bradley; Mah, Cheri D et al. (2013) The impact of circadian misalignment on athletic performance in professional football players. Sleep 36:1999-2001 |
| Bavinger, Clay; Bendavid, Eran; Niehaus, Katherine et al. (2013) Risk of cardiovascular disease from antiretroviral therapy for HIV: a systematic review. PLoS One 8:e59551 |
| Won, Joong-Ho; Jeon, Yongkweon; Rosenberg, Jarrett K et al. (2013) Uncluttered Single-Image Visualization of Vascular Structures Using GPU and Integer Programming. IEEE Trans Vis Comput Graph 19:81-93 |
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