Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37ES002611-16
Application #
2153157
Study Section
Special Emphasis Panel (NSS)
Project Start
1981-07-01
Project End
1999-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
16
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Pathology
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Neely, M D; Swift, L L; Montine, T J (2000) Human, but not bovine, oxidized cerebral spinal fluid lipoproteins disrupt neuronal microtubules. Lipids 35:1249-57
Zhang, J; Kravtsov, V; Amarnath, V et al. (2000) Enhancement of dopaminergic neurotoxicity by the mercapturate of dopamine: relevance to Parkinson's disease. J Neurochem 74:970-8
Zhang, J; Graham, D G; Montine, T J et al. (2000) Enhanced N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in mice deficient in CuZn-superoxide dismutase or glutathione peroxidase. J Neuropathol Exp Neurol 59:53-61
Picklo, M J; Amarnath, V; McIntyre, J O et al. (1999) 4-Hydroxy-2(E)-nonenal inhibits CNS mitochondrial respiration at multiple sites. J Neurochem 72:1617-24
Neely, M D; Sidell, K R; Graham, D G et al. (1999) The lipid peroxidation product 4-hydroxynonenal inhibits neurite outgrowth, disrupts neuronal microtubules, and modifies cellular tubulin. J Neurochem 72:2323-33
Picklo, M J; Amarnath, V; Graham, D G et al. (1999) Endogenous catechol thioethers may be pro-oxidant or antioxidant. Free Radic Biol Med 27:271-7
Valentine, W M; Amarnath, V; Amarnath, K et al. (1998) Covalent modification of hemoglobin by carbon disulfide: III. A potential biomarker of effect. Neurotoxicology 19:99-107
Zhang, J; Price, J O; Graham, D G et al. (1998) Secondary excitotoxicity contributes to dopamine-induced apoptosis of dopaminergic neuronal cultures. Biochem Biophys Res Commun 248:812-6
Amarnath, V; Valentine, W M; Montine, T J et al. (1998) Reactions of 4-hydroxy-2(E)-nonenal and related aldehydes with proteins studied by carbon-13 nuclear magnetic resonance spectroscopy. Chem Res Toxicol 11:317-28
Montine, K S; Olson, S J; Amarnath, V et al. (1997) Immunohistochemical detection of 4-hydroxy-2-nonenal adducts in Alzheimer's disease is associated with inheritance of APOE4. Am J Pathol 150:437-43

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