Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37GM013598-31
Application #
2168688
Study Section
Special Emphasis Panel (NSS)
Project Start
1987-06-01
Project End
1998-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
31
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Stanford University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305
Trost, Barry M; Yang, Hanbiao; Dong, Guangbin (2011) Total syntheses of bryostatins: synthesis of two ring-expanded bryostatin analogues and the development of a new-generation strategy to access the C7-C27 fragment. Chemistry 17:9789-805
Trost, Barry M; Silverman, Steven M; Stambuli, James P (2011) Development of an asymmetric trimethylenemethane cycloaddition reaction: application in the enantioselective synthesis of highly substituted carbocycles. J Am Chem Soc 133:19483-97
Trost, Barry M; Gutierrez, Alicia C; Ferreira, Eric M (2010) Differential reactivities of enyne substrates in ruthenium- and palladium-catalyzed cycloisomerizations. J Am Chem Soc 132:9206-18
Trost, Barry M; O'Boyle, Brendan M; Hund, Daniel (2010) Investigation of a domino Heck reaction for the rapid synthesis of bicyclic natural products. Chemistry 16:9772-6
Trost, Barry M; Brindle, Cheyenne S (2010) The direct catalytic asymmetric aldol reaction. Chem Soc Rev 39:1600-32
Trost, Barry M; Dong, Guangbin (2010) Total synthesis of bryostatin 16 using a Pd-catalyzed diyne coupling as macrocyclization method and synthesis of C20-epi-bryostatin 7 as a potent anticancer agent. J Am Chem Soc 132:16403-16
Trost, Barry M; Thaisrivongs, David A (2009) Palladium-catalyzed regio-, diastereo-, and enantioselective benzylic allylation of 2-substituted pyridines. J Am Chem Soc 131:12056-7
Trost, Barry M; Zhang, Yong; Zhang, Ting (2009) Direct N-carbamoylation of 3-monosubstituted oxindoles with alkyl imidazole carboxylates. J Org Chem 74:5115-7
Trost, Barry M; O'Boyle, Brendan M; Hund, Daniel (2009) Total synthesis and stereochemical assignment of (-)-ushikulide A. J Am Chem Soc 131:15061-74
Trost, Barry M; Hitce, Julien (2009) Direct asymmetric Michael addition to nitroalkenes: vinylogous nucleophilicity under dinuclear zinc catalysis. J Am Chem Soc 131:4572-3

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