Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37GM017129-26
Application #
2172016
Study Section
Special Emphasis Panel (NSS)
Project Start
1977-05-01
Project End
2000-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
26
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California Santa Cruz
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
City
Santa Cruz
State
CA
Country
United States
Zip Code
95064
Noller, Harry F (2017) The parable of the caveman and the Ferrari: protein synthesis and the RNA world. Philos Trans R Soc Lond B Biol Sci 372:
Mohan, Srividya; Noller, Harry F (2017) Recurring RNA structural motifs underlie the mechanics of L1 stalk movement. Nat Commun 8:14285
Colussi, Timothy M; Costantino, David A; Zhu, Jianyu et al. (2015) Initiation of translation in bacteria by a structured eukaryotic IRES RNA. Nature 519:110-3
Zhou, Jie; Lancaster, Laura; Donohue, John Paul et al. (2014) How the ribosome hands the A-site tRNA to the P site during EF-G-catalyzed translocation. Science 345:1188-91
Liu, Tingting; Kaplan, Ariel; Alexander, Lisa et al. (2014) Direct measurement of the mechanical work during translocation by the ribosome. Elife 3:e03406
Ramrath, David J F; Lancaster, Laura; Sprink, Thiemo et al. (2013) Visualization of two transfer RNAs trapped in transit during elongation factor G-mediated translocation. Proc Natl Acad Sci U S A 110:20964-9
Ermolenko, Dmitri N; Cornish, Peter V; Ha, Taekjip et al. (2013) Antibiotics that bind to the A site of the large ribosomal subunit can induce mRNA translocation. RNA 19:158-66
Zhou, Jie; Lancaster, Laura; Donohue, John Paul et al. (2013) Crystal structures of EF-G-ribosome complexes trapped in intermediate states of translocation. Science 340:1236086
Guo, Zhuojun; Noller, Harry F (2012) Rotation of the head of the 30S ribosomal subunit during mRNA translocation. Proc Natl Acad Sci U S A 109:20391-4
Zhu, Jianyu; Korostelev, Andrei; Costantino, David A et al. (2011) Crystal structures of complexes containing domains from two viral internal ribosome entry site (IRES) RNAs bound to the 70S ribosome. Proc Natl Acad Sci U S A 108:1839-44

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