Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
2R37GM020964-14
Application #
3484374
Study Section
Allergy and Immunology Study Section (ALY)
Project Start
1977-01-01
Project End
1991-12-31
Budget Start
1987-01-01
Budget End
1987-12-31
Support Year
14
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Institute for Cancer Research
Department
Type
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19111
Schoettler, Nathan; Ni, Dongyao; Weigert, Martin (2012) B cell receptor light chain repertoires show signs of selection with differences between groups of healthy individuals and SLE patients. Mol Immunol 51:273-82
Calcagno, Claudia; Puzone, Roberto; Pearson, Yanthe E et al. (2011) Computer simulations of heterologous immunity: highlights of an interdisciplinary cooperation. Autoimmunity 44:304-14
Louzoun, Yoram; Vider, Tal; Weigert, Martin (2006) T-cell epitope repertoire as predicted from human and viral genomes. Mol Immunol 43:559-69
Chen, Ching; Li, Hui; Tian, Qi et al. (2006) Selection of anti-double-stranded DNA B cells in autoimmune MRL-lpr/lpr mice. J Immunol 176:5183-90
Li, Yijin; Louzoun, Yoram; Weigert, Martin (2004) Editing anti-DNA B cells by Vlambdax. J Exp Med 199:337-46
Li, Yijin; Li, Hui; Ni, Dongyao et al. (2002) Anti-DNA B cells in MRL/lpr mice show altered differentiation and editing pattern. J Exp Med 196:1543-52
Detours, V; Mehr, R; Perelson, A S (2000) Deriving quantitative constraints on T cell selection from data on the mature T cell repertoire. J Immunol 164:121-8
Mehr, R; Shannon, M; Litwin, S (1999) Models for antigen receptor gene rearrangement. I. Biased receptor editing in B cells: implications for allelic exclusion. J Immunol 163:1793-8
Shannon, M; Mehr, R (1999) Reconciling repertoire shift with affinity maturation: the role of deleterious mutations. J Immunol 162:3950-6
Detours, V; Mehr, R; Perelson, A S (1999) A quantitative theory of affinity-driven T cell repertoire selection. J Theor Biol 200:389-403

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