Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37GM022854-21
Application #
2173998
Study Section
Special Emphasis Panel (NSS)
Project Start
1976-03-01
Project End
2001-02-28
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
21
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Yale University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Reynolds, Noah M; Vargas-Rodriguez, Oscar; Söll, Dieter et al. (2017) The central role of tRNA in genetic code expansion. Biochim Biophys Acta Gen Subj 1861:3001-3008
Gan, Qinglei; Fan, Chenguang (2017) Increasing the fidelity of noncanonical amino acid incorporation in cell-free protein synthesis. Biochim Biophys Acta Gen Subj 1861:3047-3052
Englert, Markus; Vargas-Rodriguez, Oscar; Reynolds, Noah M et al. (2017) A genomically modified Escherichia coli strain carrying an orthogonal E. coli histidyl-tRNA synthetase•tRNAHis pair. Biochim Biophys Acta Gen Subj 1861:3009-3015
Mukai, Takahito; Reynolds, Noah M; Crnkovi?, Ana et al. (2017) Bioinformatic Analysis Reveals Archaeal tRNATyrand tRNATrpIdentities in Bacteria. Life (Basel) 7:
Fan, Chenguang; Ip, Kevan; Söll, Dieter (2016) Expanding the genetic code of Escherichia coli with phosphotyrosine. FEBS Lett 590:3040-7
Mukai, Takahito; Englert, Markus; Tripp, H James et al. (2016) [Facile Recoding of Selenocysteine in Nature]. Angew Chem Weinheim Bergstr Ger 128:5423-5427
Dobosz-Bartoszek, Malgorzata; Pinkerton, Mark H; Otwinowski, Zbyszek et al. (2016) Crystal structures of the human elongation factor eEFSec suggest a non-canonical mechanism for selenocysteine incorporation. Nat Commun 7:12941
Gan, Qinglei; Lehman, Brent P; Bobik, Thomas A et al. (2016) Expanding the genetic code of Salmonella with non-canonical amino acids. Sci Rep 6:39920
Lajoie, M J; Söll, D; Church, G M (2016) Overcoming Challenges in Engineering the Genetic Code. J Mol Biol 428:1004-21
Hepowit, Nathaniel L; de Vera, Ian Mitchelle S; Cao, Shiyun et al. (2016) Mechanistic insight into protein modification and sulfur mobilization activities of noncanonical E1 and associated ubiquitin-like proteins of Archaea. FEBS J 283:3567-3586

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