Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37GM024486-20
Application #
2174276
Study Section
Special Emphasis Panel (NSS)
Project Start
1989-09-01
Project End
1997-11-30
Budget Start
1996-09-01
Budget End
1997-11-30
Support Year
20
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Washington University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Holt, Jo M; Klinger, Alexandra L; Yarian, Connie S et al. (2005) Asymmetric distribution of cooperativity in the binding cascade of normal human hemoglobin. 1. Cooperative and noncooperative oxygen binding in Zn-substituted hemoglobin. Biochemistry 44:11925-38
Holt, Jo M; Ackers, Gary K (2005) Asymmetric distribution of cooperativity in the binding cascade of normal human hemoglobin. 2. Stepwise cooperative free energy. Biochemistry 44:11939-49
Kaufman, R M; Lu, Z H; Behl, R et al. (2001) Lack of neighborhood effects from a transcriptionally active phosphoglycerate kinase-neo cassette located between the murine beta-major and beta-minor globin genes. Blood 98:65-73
Darling, P J; Holt, J M; Ackers, G K (2000) Coupled energetics of lambda cro repressor self-assembly and site-specific DNA operator binding I: analysis of cro dimerization from nanomolar to micromolar concentrations. Biochemistry 39:11500-7
Darling, P J; Holt, J M; Ackers, G K (2000) Coupled energetics of lambda cro repressor self-assembly and site-specific DNA operator binding II: cooperative interactions of cro dimers. J Mol Biol 302:625-38
Merabet, E K; Burz, D S; Ackers, G K (1998) Thermal melting properties of C-terminal domain mutants of bacteriophage lambda cI repressor. Methods Enzymol 295:450-67
Klinger, A L; Ackers, G K (1998) Analysis of spectra from multiwavelength oxygen-binding studies of mixed metal hybrid hemoglobins. Methods Enzymol 295:190-207
Pray, T R; Burz, D S; Ackers, G K (1998) Cooperative non-specific DNA binding by octamerizing lambda cI repressors: a site-specific thermodynamic analysis. J Mol Biol 282:947-58
Ackers, G K (1998) Deciphering the molecular code of hemoglobin allostery. Adv Protein Chem 51:185-253
Kiger, L; Klinger, A L; Kwiatkowski, L D et al. (1998) Thermodynamic studies on the equilibrium properties of a series of recombinant betaW37 hemoglobin mutants. Biochemistry 37:4336-45

Showing the most recent 10 out of 58 publications