Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37GM024544-20
Application #
2174290
Study Section
Special Emphasis Panel (NSS)
Project Start
1977-07-01
Project End
2000-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
20
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Harvard University
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
071723621
City
Cambridge
State
MA
Country
United States
Zip Code
02138
Azarova, Anna M; Lyu, Yi Lisa; Lin, Chao-Po et al. (2007) Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies. Proc Natl Acad Sci U S A 104:11014-9
Kwan, Kelvin Y; Greenwald, Rebecca J; Mohanty, Subhasis et al. (2007) Development of autoimmunity in mice lacking DNA topoisomerase 3beta. Proc Natl Acad Sci U S A 104:9242-7
Stupina, Vera A; Wang, James C (2005) Viability of Escherichia coli topA mutants lacking DNA topoisomerase I. J Biol Chem 280:355-60
Jiang, Xiaofeng (2005) Random mutagenesis of the B'A' core domain of yeast DNA topoisomerase II and large-scale screens of mutants resistant to the anticancer drug etoposide. Biochem Biophys Res Commun 327:597-603
Stupina, Vera A; Wang, James C (2004) DNA axial rotation and the merge of oppositely supercoiled DNA domains in Escherichia coli: effects of DNA bends. Proc Natl Acad Sci U S A 101:8608-13
Lyu, Yi Lisa; Wang, James C (2003) Aberrant lamination in the cerebral cortex of mouse embryos lacking DNA topoisomerase IIbeta. Proc Natl Acad Sci U S A 100:7123-8
Kwan, Kelvin Y; Moens, Peter B; Wang, James C (2003) Infertility and aneuploidy in mice lacking a type IA DNA topoisomerase III beta. Proc Natl Acad Sci U S A 100:2526-31
Wang, Yong; Lynch, A Simon; Chen, Sue-Jane et al. (2002) On the molecular basis of the thermal sensitivity of an Escherichia coli topA mutant. J Biol Chem 277:1203-9
Wang, Yong; Lyu, Yi Lisa; Wang, James C (2002) Dual localization of human DNA topoisomerase IIIalpha to mitochondria and nucleus. Proc Natl Acad Sci U S A 99:12114-9
Kwan, K Y; Wang, J C (2001) Mice lacking DNA topoisomerase IIIbeta develop to maturity but show a reduced mean lifespan. Proc Natl Acad Sci U S A 98:5717-21

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