Sequence Specific Recognition of DNA

Agency: National Institute of Health (NIH)
Institute: National Institute of General Medical Sciences (NIGMS)
Type: Method to Extend Research in Time (MERIT) Award (R37)
Project #: 2R37GM027681-16
Application #: 2356542
Study Section: Bio-Organic and Natural Products Chemistry Study Section (BNP)


NIH 2005 R37 GM	Sequence Specific Recognition of DNA Dervan, Peter B. / California Institute of Technology	$314,820
NIH 2004 R37 GM	Sequence Specific Recognition of DNA Dervan, Peter B. / California Institute of Technology	$315,832
NIH 2003 R37 GM	Sequence Specific Recognition of DNA Dervan, Peter B. / California Institute of Technology	$317,959
NIH 2002 R37 GM	Sequence Specific Recognition of DNA Dervan, Peter B. / California Institute of Technology	$326,200
NIH 2001 R37 GM	Sequence Specific Recognition of DNA Dervan, Peter B. / California Institute of Technology	$329,551
NIH 2000 R37 GM	Sequence Specific Recognition of DNA Dervan, Peter B. / California Institute of Technology	$265,475
NIH 1999 R37 GM	Sequence Specific Recognition of DNA Dervan, Peter B. / California Institute of Technology
NIH 1998 R37 GM	Sequence Specific Recognition of DNA Dervan, Peter B. / California Institute of Technology
NIH 1997 R37 GM	Sequence Specific Recognition of DNA Dervan, Peter B. / California Institute of Technology
NIH 1996 R37 GM	Sequence Specific Recognition of DNA Dervan, Peter B. / California Institute of Technology

Kurmis, Alexis A; Yang, Fei; Welch, Timothy R et al. (2017) A Pyrrole-Imidazole Polyamide Is Active against Enzalutamide-Resistant Prostate Cancer. Cancer Res 77:2207-2212

Xu, Jun; Lahiri, Indrajit; Wang, Wei et al. (2017) Structural basis for the initiation of eukaryotic transcription-coupled DNA repair. Nature 551:653-657

Xu, Liang; Wang, Wei; Gotte, Deanna et al. (2016) RNA polymerase II senses obstruction in the DNA minor groove via a conserved sensor motif. Proc Natl Acad Sci U S A 113:12426-12431

Kang, JeenJoo S; Meier, Jordan L; Dervan, Peter B (2014) Design of sequence-specific DNA binding molecules for DNA methyltransferase inhibition. J Am Chem Soc 136:3687-94

Raskatov, Jevgenij A; Szablowski, Jerzy O; Dervan, Peter B (2014) Tumor xenograft uptake of a pyrrole-imidazole (Py-Im) polyamide varies as a function of cell line grafted. J Med Chem 57:8471-6

Chenoweth, David M; Meier, Jordan L; Dervan, Peter B (2013) Pyrrole-imidazole polyamides distinguish between double-helical DNA and RNA. Angew Chem Int Ed Engl 52:415-8

Yang, Fei; Nickols, Nicholas G; Li, Benjamin C et al. (2013) Animal toxicity of hairpin pyrrole-imidazole polyamides varies with the turn unit. J Med Chem 56:7449-57

Yang, Fei; Nickols, Nicholas G; Li, Benjamin C et al. (2013) Antitumor activity of a pyrrole-imidazole polyamide. Proc Natl Acad Sci U S A 110:1863-8

Li, Benjamin C; Montgomery, David C; Puckett, James W et al. (2013) Synthesis of cyclic Py-Im polyamide libraries. J Org Chem 78:124-33

Hargrove, Amanda E; Raskatov, Jevgenij A; Meier, Jordan L et al. (2012) Characterization and solubilization of pyrrole-imidazole polyamide aggregates. J Med Chem 55:5425-32

Showing the most recent 10 out of 65 publications