Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37GM027800-17
Application #
2175017
Study Section
Special Emphasis Panel (NSS)
Project Start
1980-06-01
Project End
2000-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
17
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Pharmacology
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Wong, Kit; Van Keymeulen, Alexandra; Bourne, Henry R (2007) PDZRhoGEF and myosin II localize RhoA activity to the back of polarizing neutrophil-like cells. J Cell Biol 179:1141-8
Herzmark, Paul; Campbell, Kyle; Wang, Fei et al. (2007) Bound attractant at the leading vs. the trailing edge determines chemotactic prowess. Proc Natl Acad Sci U S A 104:13349-54
Xu, Jingsong; Van Keymeulen, Alexandra; Wakida, Nicole M et al. (2007) Polarity reveals intrinsic cell chirality. Proc Natl Acad Sci U S A 104:9296-300
Van Keymeulen, Alexandra; Wong, Kit; Knight, Zachary A et al. (2006) To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front. J Cell Biol 174:437-45
Weiner, Orion D; Rentel, Maike C; Ott, Alex et al. (2006) Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis. PLoS Biol 4:e38
Wong, Kit; Pertz, Olivier; Hahn, Klaus et al. (2006) Neutrophil polarization: spatiotemporal dynamics of RhoA activity support a self-organizing mechanism. Proc Natl Acad Sci U S A 103:3639-44
Xu, Jingsong; Wang, Fei; Van Keymeulen, Alexandra et al. (2005) Neutrophil microtubules suppress polarity and enhance directional migration. Proc Natl Acad Sci U S A 102:6884-9
Srinivasan, Supriya; Wang, Fei; Glavas, Suzana et al. (2003) Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis. J Cell Biol 160:375-85
Yu, Wei; O'Brien, Lucy E; Wang, Fei et al. (2003) Hepatocyte growth factor switches orientation of polarity and mode of movement during morphogenesis of multicellular epithelial structures. Mol Biol Cell 14:748-63
Whistler, Jennifer L; Gerber, Basil O; Meng, Elaine C et al. (2002) Constitutive activation and endocytosis of the complement factor 5a receptor: evidence for multiple activated conformations of a G protein-coupled receptor. Traffic 3:866-77

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