Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37GM029210-24
Application #
6342780
Study Section
Special Emphasis Panel (NSS)
Program Officer
Shapiro, Bert I
Project Start
1981-01-01
Project End
2004-12-31
Budget Start
2001-01-01
Budget End
2001-12-31
Support Year
24
Fiscal Year
2001
Total Cost
$687,015
Indirect Cost
Name
Albert Einstein College of Medicine
Department
Physiology
Type
Schools of Medicine
DUNS #
009095365
City
Bronx
State
NY
Country
United States
Zip Code
10461
Schiffmiller, Aviva; Anderson, Damon; Finkelstein, Alan (2015) Ion selectivity of the anthrax toxin channel and its effect on protein translocation. J Gen Physiol 146:183-92
Schiffmiller, Aviva; Finkelstein, Alan (2015) Ion conductance of the stem of the anthrax toxin channel during lethal factor translocation. J Mol Biol 427:1211-23
Kienker, Paul K; Wu, Zhengyan; Finkelstein, Alan (2015) Mapping the membrane topography of the TH6-TH7 segment of the diphtheria toxin T-domain channel. J Gen Physiol 145:107-25
Udho, Eshwar; Jakes, Karen S; Finkelstein, Alan (2012) TonB-dependent transporter FhuA in planar lipid bilayers: partial exit of its plug from the barrel. Biochemistry 51:6753-9
Basilio, Daniel; Kienker, Paul K; Briggs, Stephen W et al. (2011) A kinetic analysis of protein transport through the anthrax toxin channel. J Gen Physiol 137:521-31
Rodnin, Mykola V; Kyrychenko, Alexander; Kienker, Paul et al. (2011) Replacement of C-terminal histidines uncouples membrane insertion and translocation in diphtheria toxin T-domain. Biophys J 101:L41-3
Basilio, Daniel; Jennings-Antipov, Laura D; Jakes, Karen S et al. (2011) Trapping a translocating protein within the anthrax toxin channel: implications for the secondary structure of permeating proteins. J Gen Physiol 137:343-56
Rodnin, Mykola V; Kyrychenko, Alexander; Kienker, Paul et al. (2010) Conformational switching of the diphtheria toxin T domain. J Mol Biol 402:1-7
Jakes, Karen S; Finkelstein, Alan (2010) The colicin Ia receptor, Cir, is also the translocator for colicin Ia. Mol Microbiol 75:567-78
Janowiak, Blythe E; Finkelstein, Alan; Collier, R John (2009) An approach to characterizing single-subunit mutations in multimeric prepores and pores of anthrax protective antigen. Protein Sci 18:348-58

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