Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37GM031756-23
Application #
6722632
Study Section
Special Emphasis Panel (NSS)
Program Officer
Ikeda, Richard A
Project Start
1982-08-01
Project End
2009-07-31
Budget Start
2004-08-01
Budget End
2005-07-31
Support Year
23
Fiscal Year
2004
Total Cost
$415,107
Indirect Cost
Name
University of Illinois Urbana-Champaign
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
041544081
City
Champaign
State
IL
Country
United States
Zip Code
61820
Denisov, Ilia G; Sligar, Stephen G (2017) Nanodiscs in Membrane Biochemistry and Biophysics. Chem Rev 117:4669-4713
Mak, Piotr J; Luthra, Abhinav; Sligar, Stephen G et al. (2014) Resonance Raman spectroscopy of the oxygenated intermediates of human CYP19A1 implicates a compound i intermediate in the final lyase step. J Am Chem Soc 136:4825-8
Khatri, Yogan; Gregory, Michael C; Grinkova, Yelena V et al. (2014) Active site proton delivery and the lyase activity of human CYP17A1. Biochem Biophys Res Commun 443:179-84
Khatri, Yogan; Luthra, Abhinav; Duggal, Ruchia et al. (2014) Kinetic solvent isotope effect in steady-state turnover by CYP19A1 suggests involvement of Compound 1 for both hydroxylation and aromatization steps. FEBS Lett 588:3117-22
Mak, Piotr J; Gregory, Michael C; Sligar, Stephen G et al. (2014) Resonance Raman spectroscopy reveals that substrate structure selectively impacts the heme-bound diatomic ligands of CYP17. Biochemistry 53:90-100
Gregory, Michael C; Denisov, Ilia G; Grinkova, Yelena V et al. (2013) Kinetic solvent isotope effect in human P450 CYP17A1-mediated androgen formation: evidence for a reactive peroxoanion intermediate. J Am Chem Soc 135:16245-7
Sun, Yuhan; Zeng, Weiqiao; Benabbas, Abdelkrim et al. (2013) Investigations of heme ligation and ligand switching in cytochromes p450 and p420. Biochemistry 52:5941-51
Numata, Mari; Grinkova, Yelena V; Mitchell, James R et al. (2013) Nanodiscs as a therapeutic delivery agent: inhibition of respiratory syncytial virus infection in the lung. Int J Nanomedicine 8:1417-27
Schuler, Mary A; Denisov, Ilia G; Sligar, Stephen G (2013) Nanodiscs as a new tool to examine lipid-protein interactions. Methods Mol Biol 974:415-33
Luthra, A; Gregory, M; Grinkova, Y V et al. (2013) Nanodiscs in the studies of membrane-bound cytochrome P450 enzymes. Methods Mol Biol 987:115-27

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