Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37GM034095-18
Application #
6258604
Study Section
Special Emphasis Panel (NSS)
Program Officer
Anderson, James J
Project Start
1984-07-01
Project End
2006-06-30
Budget Start
2001-07-01
Budget End
2002-06-30
Support Year
18
Fiscal Year
2001
Total Cost
$507,186
Indirect Cost
Name
Columbia University (N.Y.)
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032
Ruiz, Amparo; Xu, Xinjing; Carlson, Marian (2013) Ptc1 protein phosphatase 2C contributes to glucose regulation of SNF1/AMP-activated protein kinase (AMPK) in Saccharomyces cerevisiae. J Biol Chem 288:31052-8
Ruiz, Amparo; Liu, Yang; Xu, Xinjing et al. (2012) Heterotrimer-independent regulation of activation-loop phosphorylation of Snf1 protein kinase involves two protein phosphatases. Proc Natl Acad Sci U S A 109:8652-7
Momcilovic, Milica; Carlson, Marian (2011) Alterations at dispersed sites cause phosphorylation and activation of SNF1 protein kinase during growth on high glucose. J Biol Chem 286:23544-51
Ruiz, Amparo; Xu, Xinjing; Carlson, Marian (2011) Roles of two protein phosphatases, Reg1-Glc7 and Sit4, and glycogen synthesis in regulation of SNF1 protein kinase. Proc Natl Acad Sci U S A 108:6349-54
Liu, Yang; Xu, Xinjing; Carlson, Marian (2011) Interaction of SNF1 protein kinase with its activating kinase Sak1. Eukaryot Cell 10:313-9
Amodeo, Gabriele A; Momcilovic, Milica; Carlson, Marian et al. (2010) Biochemical and functional studies on the regulation of the Saccharomyces cerevisiae AMPK homolog SNF1. Biochem Biophys Res Commun 397:197-201
Momcilovic, Milica; Iram, Surtaj H; Liu, Yang et al. (2008) Roles of the glycogen-binding domain and Snf4 in glucose inhibition of SNF1 protein kinase. J Biol Chem 283:19521-9
Rudolph, Michael J; Amodeo, Gabriele A; Iram, Surtaj H et al. (2007) Structure of the Bateman2 domain of yeast Snf4: dimeric association and relevance for AMP binding. Structure 15:65-74
Hong, Seung-Pyo; Carlson, Marian (2007) Regulation of snf1 protein kinase in response to environmental stress. J Biol Chem 282:16838-45
Orlova, Marianna; Kanter, Ellen; Krakovich, David et al. (2006) Nitrogen availability and TOR regulate the Snf1 protein kinase in Saccharomyces cerevisiae. Eukaryot Cell 5:1831-7

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