Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37GM034182-13
Application #
2177325
Study Section
Special Emphasis Panel (NSS)
Project Start
1984-06-01
Project End
1998-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
13
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Saint Louis University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
City
Saint Louis
State
MO
Country
United States
Zip Code
63103

  Publications

Urayama, Akihiko; Grubb, Jeffrey H; Sly, William S et al. (2016) Pharmacologic manipulation of lysosomal enzyme transport across the blood-brain barrier. J Cereb Blood Flow Metab 36:476-86
Tomatsu, Shunji; Yasuda, Eriko; Patel, Pravin et al. (2014) Morquio A syndrome: diagnosis and current and future therapies. Pediatr Endocrinol Rev 12 Suppl 1:141-51
Sly, William S; Vogler, Carole (2013) The final frontier -- crossing the blood-brain barrier. EMBO Mol Med 5:655-7
Arechederra, Robert L; Waheed, Abdul; Sly, William S et al. (2013) Effect of sulfonamides as carbonic anhydrase VA and VB inhibitors on mitochondrial metabolic energy conversion. Bioorg Med Chem 21:1544-8
Rowan, Daniel J; Tomatsu, Shunji; Grubb, Jeffrey H et al. (2013) Assessment of bone dysplasia by micro-CT and glycosaminoglycan levels in mouse models for mucopolysaccharidosis type I, IIIA, IVA, and VII. J Inherit Metab Dis 36:235-46
Schneider, Hans-Peter; Alt, Marco D; Klier, Michael et al. (2013) GPI-anchored carbonic anhydrase IV displays both intra- and extracellular activity in cRNA-injected oocytes and in mouse neurons. Proc Natl Acad Sci U S A 110:1494-9
Huynh, Ha T; Grubb, Jeffrey H; Vogler, Carole et al. (2012) Biochemical evidence for superior correction of neuronal storage by chemically modified enzyme in murine mucopolysaccharidosis VII. Proc Natl Acad Sci U S A 109:17022-7
McIntyre, Alan; Patiar, Shalini; Wigfield, Simon et al. (2012) Carbonic anhydrase IX promotes tumor growth and necrosis in vivo and inhibition enhances anti-VEGF therapy. Clin Cancer Res 18:3100-11
Makani, Sachin; Chen, Huei-Ying; Esquenazi, Susana et al. (2012) NMDA receptor-dependent afterdepolarizations are curtailed by carbonic anhydrase 14: regulation of a short-term postsynaptic potentiation. J Neurosci 32:16754-62
Rowan, Daniel J; Tomatsu, Shunji; Grubb, Jeffrey H et al. (2012) Long circulating enzyme replacement therapy rescues bone pathology in mucopolysaccharidosis VII murine model. Mol Genet Metab 107:161-72

Showing the most recent 10 out of 133 publications