Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37GM034277-18
Application #
6519164
Study Section
Special Emphasis Panel (NSS)
Program Officer
Rhoades, Marcus M
Project Start
1984-12-01
Project End
2005-03-31
Budget Start
2002-04-01
Budget End
2003-03-31
Support Year
18
Fiscal Year
2002
Total Cost
$421,006
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Internal Medicine/Medicine
Type
Schools of Arts and Sciences
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Wu, Xuebing; Scott, David A; Kriz, Andrea J et al. (2014) Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells. Nat Biotechnol 32:670-6
Wu, Xuebing; Kriz, Andrea J; Sharp, Phillip A (2014) Target specificity of the CRISPR-Cas9 system. Quant Biol 2:59-70
Sigova, Alla A; Mullen, Alan C; Molinie, Benoit et al. (2013) Divergent transcription of long noncoding RNA/mRNA gene pairs in embryonic stem cells. Proc Natl Acad Sci U S A 110:2876-81
Cheng, Chonghui; Sharp, Phillip A (2006) Regulation of CD44 alternative splicing by SRm160 and its potential role in tumor cell invasion. Mol Cell Biol 26:362-70
Hakre, Shweta; Tussie-Luna, Maria Isabel; Ashworth, Todd et al. (2006) Opposing functions of TFII-I spliced isoforms in growth factor-induced gene expression. Mol Cell 24:301-8
Grishok, Alla; Sinskey, Jina L; Sharp, Phillip A (2005) Transcriptional silencing of a transgene by RNAi in the soma of C. elegans. Genes Dev 19:683-96
Grishok, Alla; Sharp, Phillip A (2005) Negative regulation of nuclear divisions in Caenorhabditis elegans by retinoblastoma and RNA interference-related genes. Proc Natl Acad Sci U S A 102:17360-5
Houbaviy, Hristo B; Dennis, Lucas; Jaenisch, Rudolf et al. (2005) Characterization of a highly variable eutherian microRNA gene. RNA 11:1245-57
Lee, Keng Boon; Sharp, Phillip A (2004) Transcription-dependent polyubiquitination of RNA polymerase II requires lysine 63 of ubiquitin. Biochemistry 43:15223-9
Ventura, Andrea; Meissner, Alexander; Dillon, Christopher P et al. (2004) Cre-lox-regulated conditional RNA interference from transgenes. Proc Natl Acad Sci U S A 101:10380-5

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