Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37GM036259-12
Application #
2178246
Study Section
Special Emphasis Panel (NSS)
Project Start
1985-07-01
Project End
1999-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115
Shiroto, Takashi; Romero, Natalia; Sugiyama, Toru et al. (2014) Caveolin-1 is a critical determinant of autophagy, metabolic switching, and oxidative stress in vascular endothelium. PLoS One 9:e87871
Sartoretto, Juliano L; Kalwa, Hermann; Romero, Natalia et al. (2013) In vivo imaging of nitric oxide and hydrogen peroxide in cardiac myocytes. Methods Enzymol 528:61-78
Bretón-Romero, Rosa; Kalwa, Hermann; Lamas, Santiago et al. (2013) Role of PTEN in modulation of ADP-dependent signaling pathways in vascular endothelial cells. Biochim Biophys Acta 1833:2586-2595
Kalwa, Hermann; Sartoretto, Juliano L; Sartoretto, Simone M et al. (2012) Angiotensin-II and MARCKS: a hydrogen peroxide- and RAC1-dependent signaling pathway in vascular endothelium. J Biol Chem 287:29147-58
Jin, Benjamin Y; Lin, Alison J; Golan, David E et al. (2012) MARCKS protein mediates hydrogen peroxide regulation of endothelial permeability. Proc Natl Acad Sci U S A 109:14864-9
Sartoretto, Juliano L; Kalwa, Hermann; Shiroto, Takashi et al. (2012) Role of Ca2+ in the control of H2O2-modulated phosphorylation pathways leading to eNOS activation in cardiac myocytes. PLoS One 7:e44627
Kou, Ruqin; Shiroto, Takashi; Sartoretto, Juliano L et al. (2012) Suppression of G?s synthesis by simvastatin treatment of vascular endothelial cells. J Biol Chem 287:2643-51
Kalwa, Hermann; Michel, Thomas (2011) The MARCKS protein plays a critical role in phosphatidylinositol 4,5-bisphosphate metabolism and directed cell movement in vascular endothelial cells. J Biol Chem 286:2320-30
Sartoretto, Juliano L; Kalwa, Hermann; Pluth, Michael D et al. (2011) Hydrogen peroxide differentially modulates cardiac myocyte nitric oxide synthesis. Proc Natl Acad Sci U S A 108:15792-7
Sugiyama, Toru; Michel, Thomas (2010) Thiol-metabolizing proteins and endothelial redox state: differential modulation of eNOS and biopterin pathways. Am J Physiol Heart Circ Physiol 298:H194-201

Showing the most recent 10 out of 66 publications