Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37GM038627-11
Application #
2179436
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1988-09-01
Project End
1997-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Harvard University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
071723621
City
Cambridge
State
MA
Country
United States
Zip Code
02138
Leshchiner, Elizaveta S; Rush, Jason S; Durney, Michael A et al. (2017) Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease. Proc Natl Acad Sci U S A 114:11392-11397
Nelson Jr, Shawn D; Wawer, Mathias J; Schreiber, Stuart L (2016) Divergent Synthesis and Real-Time Biological Annotation of Optically Active Tetrahydrocyclopenta[c]pyranone Derivatives. Org Lett 18:6280-6283
Gerry, Christopher J; Hua, Bruce K; Wawer, Mathias J et al. (2016) Real-Time Biological Annotation of Synthetic Compounds. J Am Chem Soc 138:8920-7
Scully, Stephen S; Zheng, Shao-Liang; Wagner, Bridget K et al. (2015) Synthesis of oxazocenones via gold(I)-catalyzed 8-endo-dig hydroalkoxylation of alkynamides. Org Lett 17:418-21
Iaconelli, Jonathan; Huang, Joanne H; Berkovitch, Shaunna S et al. (2015) HDAC6 inhibitors modulate Lys49 acetylation and membrane localization of ?-catenin in human iPSC-derived neuronal cells. ACS Chem Biol 10:883-90
Abazeed, Mohamed E; Adams, Drew J; Hurov, Kristen E et al. (2013) Integrative radiogenomic profiling of squamous cell lung cancer. Cancer Res 73:6289-98
Schaefer, Giannina I; Perez, José R; Duvall, Jeremy R et al. (2013) Discovery of small-molecule modulators of the Sonic Hedgehog pathway. J Am Chem Soc 135:9675-80
Yuan, Y; Tang, A J; Castoreno, A B et al. (2013) Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cells. Cell Death Dis 4:e690
Ignatenko, Vasily A; Han, Yong; Tochtrop, Gregory P (2013) Molecular library synthesis using complex substrates: expanding the framework of triterpenoids. J Org Chem 78:410-8
Yuan, Yuan; Hartland, Kate; Boskovic, Zarko et al. (2013) A small-molecule inducer of PDX1 expression identified by high-throughput screening. Chem Biol 20:1513-22

Showing the most recent 10 out of 88 publications