Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37GM041890-16
Application #
6689025
Study Section
Special Emphasis Panel (NSS)
Program Officer
Ikeda, Richard A
Project Start
1995-04-01
Project End
2009-03-31
Budget Start
2004-04-01
Budget End
2005-03-31
Support Year
16
Fiscal Year
2004
Total Cost
$437,507
Indirect Cost
Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02215
Thorpe, Lauren M; Spangle, Jennifer M; Ohlson, Carolynn E et al. (2017) PI3K-p110? mediates the oncogenic activity induced by loss of the novel tumor suppressor PI3K-p85?. Proc Natl Acad Sci U S A 114:7095-7100
Lee, Ho-Joon; Jedrychowski, Mark P; Vinayagam, Arunachalam et al. (2017) Proteomic and Metabolomic Characterization of a Mammalian Cellular Transition from Quiescence to Proliferation. Cell Rep 20:721-736
Fruman, David A; Chiu, Honyin; Hopkins, Benjamin D et al. (2017) The PI3K Pathway in Human Disease. Cell 170:605-635
Hu, Hai; Juvekar, Ashish; Lyssiotis, Costas A et al. (2016) Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton. Cell 164:433-46
Davis, Mindy I; Sasaki, Atsuo T; Shen, Min et al. (2013) A homogeneous, high-throughput assay for phosphatidylinositol 5-phosphate 4-kinase with a novel, rapid substrate preparation. PLoS One 8:e54127
Klempner, Samuel J; Myers, Andrea P; Cantley, Lewis C (2013) What a tangled web we weave: emerging resistance mechanisms to inhibition of the phosphoinositide 3-kinase pathway. Cancer Discov 3:1345-54
Juvekar, Ashish; Burga, Laura N; Hu, Hai et al. (2012) Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer. Cancer Discov 2:1048-63
Alenghat, Francis J; Baca, Quentin J; Rubin, Nooreen T et al. (2012) Macrophages require Skap2 and Sirp? for integrin-stimulated cytoskeletal rearrangement. J Cell Sci 125:5535-45
Sasaki, Atsuo T; Carracedo, Arkaitz; Locasale, Jason W et al. (2011) Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors. Sci Signal 4:ra13
Lee, Jennifer Y; Chiu, Yu-Hsin; Asara, John et al. (2011) Inhibition of PI3K binding to activators by serine phosphorylation of PI3K regulatory subunit p85alpha Src homology-2 domains. Proc Natl Acad Sci U S A 108:14157-62

Showing the most recent 10 out of 103 publications