Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37GM051796-12
Application #
7087685
Study Section
Special Emphasis Panel (NSS)
Program Officer
Marino, Pamela
Project Start
1998-07-01
Project End
2009-06-30
Budget Start
2006-07-01
Budget End
2007-06-30
Support Year
12
Fiscal Year
2006
Total Cost
$375,953
Indirect Cost
Name
Duke University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Sohlenkamp, Christian; Raetz, Christian R H; Ingram, Brian O (2013) The calcium-stimulated lipid A 3-O deacylase from Rhizobium etli is not essential for plant nodulation. Biochim Biophys Acta 1831:1250-9
Sohlenkamp, Christian; Raetz, Christian R H; Ingram, Brian O (2012) The calcium-stimulated lipid A 3-O deacylase from Rhizobium etli is not essential for plant nodulation. Biochim Biophys Acta 1831:1250-9
Kong, Qingke; Six, David A; Liu, Qing et al. (2012) Phosphate groups of lipid A are essential for Salmonella enterica serovar Typhimurium virulence and affect innate and adaptive immunity. Infect Immun 80:3215-24
Kanistanon, Duangjit; Powell, Daniel A; Hajjar, Adeline M et al. (2012) Role of Francisella lipid A phosphate modification in virulence and long-term protective immune responses. Infect Immun 80:943-51
Kong, Qingke; Six, David A; Liu, Qing et al. (2011) Palmitoylation state impacts induction of innate and acquired immunity by the Salmonella enterica serovar typhimurium msbB mutant. Infect Immun 79:5027-38
Lu, Yi-Hsueh; Guan, Ziqiang; Zhao, Jinshi et al. (2011) Three phosphatidylglycerol-phosphate phosphatases in the inner membrane of Escherichia coli. J Biol Chem 286:5506-18
Kong, Qingke; Six, David A; Roland, Kenneth L et al. (2011) Salmonella synthesizing 1-dephosphorylated [corrected] lipopolysaccharide exhibits low endotoxic activity while retaining its immunogenicity. J Immunol 187:412-23
Chung, Hak Suk; Raetz, Christian R H (2011) Dioxygenases in Burkholderia ambifaria and Yersinia pestis that hydroxylate the outer Kdo unit of lipopolysaccharide. Proc Natl Acad Sci U S A 108:510-5
Stead, Christopher M; Zhao, Jinshi; Raetz, Christian R H et al. (2010) Removal of the outer Kdo from Helicobacter pylori lipopolysaccharide and its impact on the bacterial surface. Mol Microbiol 78:837-52
Ingram, Brian O; Masoudi, Ali; Raetz, Christian R H (2010) Escherichia coli mutants that synthesize dephosphorylated lipid A molecules. Biochemistry 49:8325-37

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