Abstract

Long-term objective is knowledge of the factors that determine and regulate the metabolic exchange between mother, placenta, and fetus. The solution of important health related problems, such as detection and prevention of fetal hypoxia, malnutrition, and growth disorders, depends on the acquisition of this basic knowledge.
The specific aims are: (1) to study placental oxygen transport in twin-pregnant ewes that carry hemoglobins with different oxygen affinities. (2) to study developmental changes in placental glucose transport, (3) to test the hypothesis that the serine metabolized by the placenta is primarily of fetal origin. (4) to study the effect of undernutrition on uteroplacental metabolism and placental oxygen transport, and (5) to study mechanisms of fetal lactate and pH regulation in a controlled sae of fetal hypoxia associated with a significant decrease in fetal oxygen uptake. The studies will be performed in chronic sheep preparations. The maternal-placental-fetal exchange will be quantitated by using techniques of blood flow measurement, chemical analysis of maternal arterial, uterine venous, umbilical arterial and venous blood, and tracer methodology.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
2R37HD001866-24
Application #
3484901
Study Section
Reproductive Biology Study Section (REB)
Project Start
1977-02-01
Project End
1993-01-31
Budget Start
1989-02-01
Budget End
1990-01-31
Support Year
24
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
University of Colorado Denver
Department
Type
Schools of Medicine
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045

  Publications

Ashrafi, Ghazaleh; Schlehe, Julia S; LaVoie, Matthew J et al. (2014) Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin. J Cell Biol 206:655-70
Jozwik, M; Teng, C; Timmerman, M et al. (1998) Uptake and transport by the ovine placenta of neutral nonmetabolizable amino acids with different transport system affinities. Placenta 19:531-8
Chung, M; Teng, C; Timmerman, M et al. (1998) Production and utilization of amino acids by ovine placenta in vivo. Am J Physiol 274:E13-22
Barbera, A; Wilkening, R B; Teng, C et al. (1997) Metabolic alterations in the fetal hepatic and umbilical circulations during glucocorticoid-induced parturition in sheep. Pediatr Res 41:242-8
Ross, J C; Fennessey, P V; Wilkening, R B et al. (1996) Placental transport and fetal utilization of leucine in a model of fetal growth retardation. Am J Physiol 270:E491-503
Carter, B S; Moores Jr, R R; Teng, C et al. (1995) Main routes of plasma lactate carbon disposal in the midgestation fetal lamb. Biol Neonate 67:295-300
Barbera, A; Jones 3rd, O W; Zerbe, G O et al. (1995) Early ultrasonographic detection of fetal growth retardation in an ovine model of placental insufficiency. Am J Obstet Gynecol 173:1071-4
Wilkening, R B; Boyle, D W; Teng, C et al. (1994) Amino acid uptake by the fetal ovine hindlimb under normal and euglycemic hyperinsulinemic states. Am J Physiol 266:E72-8
Wilkening, R B; Boyle, D W; Meschia, G (1993) Fetal pH improvement after 24 h of severe, nonlethal hypoxia. Biol Neonate 63:129-32
Guyton, T S; De Wilt, H; Fennessey, P V et al. (1993) Alanine umbilical uptake, disposal rate, and decarboxylation rate in the fetal lamb. Am J Physiol 265:E497-503

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