Project Start
1978-09-29
Project End
1999-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
27
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Hsu, Mei-Hui; Savas, Uzen; Lasker, Jerome M et al. (2011) Genistein, resveratrol, and 5-aminoimidazole-4-carboxamide-1-?-D-ribofuranoside induce cytochrome P450 4F2 expression through an AMP-activated protein kinase-dependent pathway. J Pharmacol Exp Ther 337:125-36
Savas, Uzen; Machemer, Daniel E W; Hsu, Mei-Hui et al. (2009) Opposing roles of peroxisome proliferator-activated receptor alpha and growth hormone in the regulation of CYP4A11 expression in a transgenic mouse model. J Biol Chem 284:16541-52
Hsu, Mei-Hui; Savas, Uzen; Griffin, Keith J et al. (2007) Human cytochrome p450 family 4 enzymes: function, genetic variation and regulation. Drug Metab Rev 39:515-38
Hsu, Mei-Hui; Savas, Uzen; Griffin, Keith J et al. (2007) Regulation of human cytochrome P450 4F2 expression by sterol regulatory element-binding protein and lovastatin. J Biol Chem 282:5225-36
Savas, Uzen; Hsu, Mei-Hui; Griffin, Keith J et al. (2005) Conditional regulation of the human CYP4X1 and CYP4Z1 genes. Arch Biochem Biophys 436:377-85
Savas, Uzen; Hsu, Mei-Hui; Johnson, Eric F (2003) Differential regulation of human CYP4A genes by peroxisome proliferators and dexamethasone. Arch Biochem Biophys 409:212-20
Cowart, L Ashley; Wei, Shouzuo; Hsu, Mei-Hui et al. (2002) The CYP4A isoforms hydroxylate epoxyeicosatrienoic acids to form high affinity peroxisome proliferator-activated receptor ligands. J Biol Chem 277:35105-12
Johnson, Eric F; Hsu, Mei-Hui; Savas, Uzen et al. (2002) Regulation of P450 4A expression by peroxisome proliferator activated receptors. Toxicology 181-182:203-6
Hsu, M H; Savas, U; Griffin, K J et al. (2001) Identification of peroxisome proliferator-responsive human genes by elevated expression of the peroxisome proliferator-activated receptor alpha in HepG2 cells. J Biol Chem 276:27950-8
Savas, U; Wester, M R; Griffin, K J et al. (2000) Rabbit pregnane X receptor is activated by rifampicin. Drug Metab Dispos 28:529-37

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